用于合成β-琥珀酰亚胺硫化物的烯烃三组分串联氨硫基化反应
Three-Component Tandem Amidosulfenylation of Alkenes for the Synthesis of β-Succinimide Sulfides.
作者信息
Yao Lin, Li Wenjian, Xiao Fuhong, Deng Guo-Jun
机构信息
Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, Hunan Province Key Laboratory of Green Organic Synthesis and Application, College of Chemistry, Xiangtan University, Xiangtan 411105, China.
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China.
出版信息
J Org Chem. 2023 Oct 6;88(19):13956-13966. doi: 10.1021/acs.joc.3c01518. Epub 2023 Sep 12.
An environmentally benign multicomponent strategy for the amidosulfenylation of alkenes for the synthesis of β-succinimide sulfides is disclosed. In this process, common disulfides smoothly act as a sulfur-based source, and -iodosuccinimide (NIS) is used not only as a free radical initiator but also as an -nucleophile. A broad range of functional groups are tolerated in this reaction system.
公开了一种用于烯烃氨硫基化反应以合成β-琥珀酰亚胺硫化物的环境友好型多组分策略。在此过程中，常见的二硫化物可顺利充当硫源，且N-碘代琥珀酰亚胺（NIS）不仅用作自由基引发剂，还用作亲核试剂。该反应体系能耐受多种官能团。
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