内镜袖状胃切除术治疗后中期体重减轻及合并症缓解的系统评价和荟萃分析。

Medium-Term Weight Loss and Remission of Comorbidities Following Endoscopic Sleeve Gastroplasty: a Systematic Review and Meta-analysis.

机构信息

Department of Surgery and Cancer, Imperial College London, London, UK.

Department of Upper Gastrointestinal and Bariatric Surgery, St. George's University Hospitals NHS Foundation Trust, London, UK.

出版信息

Obes Surg. 2023 Nov;33(11):3527-3538. doi: 10.1007/s11695-023-06778-x. Epub 2023 Sep 13.

This systematic review and meta-analysis aimed to determine the short- and medium-term weight loss outcomes and comorbidity resolution following endoscopic sleeve gastroplasty. Our search identified 35 relevant studies containing data from 7525 patients. Overall, pooled short-term (12 months) total weight loss (TWL) was 16.2% (95% CI 13.1-19.4%) in 23 studies (n = 5659). Pooled medium-term TWL was 15.4% (95% CI 13.7-17.2%) in 10 studies (n = 4040). Diabetes resolution was 55.4% (95% CI 46-64%), hypertension resolution was 62.8% (95% CI 43-82%), dyslipidaemia resolution was 56.3% (95% CI 49-63%), and obstructive sleep apnoea resolution was 51.7% (95% CI 16.2-87.3%) in four studies (n = 480). This pooled analysis demonstrates that ESG can induce durable weight loss and resolution of obesity-associated comorbidities in patients with moderate obesity.

本系统评价和荟萃分析旨在确定内镜袖状胃成形术治疗后短期和中期的体重减轻效果和合并症缓解情况。我们的检索共确定了 35 项相关研究，这些研究共包含 7525 名患者的数据。总体而言，23 项研究（n = 5659）的短期（12 个月）总减重（TWL）的汇总结果为 16.2%（95%CI 13.1-19.4%）。10 项研究（n = 4040）的中期 TWL 汇总结果为 15.4%（95%CI 13.7-17.2%）。四项研究（n = 480）中，糖尿病缓解率为 55.4%（95%CI 46-64%），高血压缓解率为 62.8%（95%CI 43-82%），血脂异常缓解率为 56.3%（95%CI 49-63%），阻塞性睡眠呼吸暂停缓解率为 51.7%（95%CI 16.2-87.3%）。该汇总分析表明，ESG 可诱导中度肥胖患者持久的体重减轻和肥胖相关合并症的缓解。