Täuber U, Schröder K, Düsterberg B, Matthes H
Eur J Drug Metab Pharmacokinet. 1986 Apr-Jun;11(2):145-9. doi: 10.1007/BF03189840.
The plasma levels of testosterone (T) were measured after oral administration of 25 mg T and 40 mg testosterone-undecanoate (TU) in a group of young women by a specific radioimmunoassay. Plasma levels were compared to those after intravenous administration of 1.5 micrograms testosterone/kg to another group of young women for determination of absolute bioavailability. Due to the high metabolic clearance rate of 24.5 ml/min/kg absolute systemic availability of free testosterone was calculated to 3.56 +/- 2.45%. Oral administration of testosterone undecanoate leads only to an absolute testosterone bioavailability of 6.83 +/- 3.32%.
通过特定放射免疫分析法，对一组年轻女性口服25毫克睾酮（T）和40毫克十一酸睾酮（TU）后的血浆睾酮水平进行了测量。将这些血浆水平与另一组年轻女性静脉注射1.5微克睾酮/千克后的血浆水平进行比较，以确定绝对生物利用度。由于代谢清除率高达24.5毫升/分钟/千克，计算得出游离睾酮的绝对全身利用率为3.56±2.45%。口服十一酸睾酮的绝对睾酮生物利用度仅为6.83±3.32%。
