School of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Liver Transplant Unit, Queen Elizabeth Hospital, Birmingham, UK.
BMC Gastroenterol. 2023 Sep 12;23(1):306. doi: 10.1186/s12876-023-02941-x.
Non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease in wealthy societies, and is responsible for a significant rise in liver morbidity and mortality. Current treatments prioritise lifestyle interventions, predominantly diet and exercise management, but patients frequently fail to make the necessary behavioural adjustments. The current study seeks to identify those factors which influence patients' behaviour with respect to adherence to treatment regimes.
Novel areas of interest were investigated; locus of control, behavioural regulation and a range of mental health measures, due to their links to either poor lifestyle choices or abnormal eating as identified in previous literature. Data was gathered using self-report questionnaires, from 96 participants, who were split into three groups, NAFLD patients, non-NAFLD liver disease patients and healthy controls RESULTS: Data was analysed using a MANOVA, and followed up with a Tukey post-hoc test. Three factors were found to be significant by group; cognitive restraint, uncontrolled eating and SAPAS score (a measure of personality disorders). An association between personality disorders and NAFLD was identified.
It is suggested that NAFLD patients are screened for personality disorders and, if identified, treated prior to the commencement of diet and exercise management.
非酒精性脂肪性肝病（NAFLD）已成为富裕社会中慢性肝病的最常见病因，也是导致肝发病率和死亡率显著上升的主要原因。目前的治疗方法侧重于生活方式干预，主要是饮食和运动管理，但患者经常无法进行必要的行为调整。本研究旨在确定影响患者治疗方案依从性的行为因素。
由于先前的文献表明，控制源、行为调节和一系列心理健康措施与不良生活方式选择或异常饮食有关，因此研究调查了新的兴趣领域。使用自我报告问卷从 96 名参与者中收集数据，这些参与者分为三组：NAFLD 患者、非 NAFLD 肝病患者和健康对照组。
使用 MANOVA 进行数据分析，并进行了 Tukey 事后检验。通过组发现三个因素是显著的；认知约束、失控饮食和 SAPAS 评分（人格障碍的一种衡量标准）。确定了人格障碍与 NAFLD 之间的关联。
建议对 NAFLD 患者进行人格障碍筛查，如果发现，在开始饮食和运动管理之前进行治疗。
