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中国居民臭氧污染与哮喘急性加重：一项生态学研究。

Ozone Pollution and Acute Exacerbation of Asthma in Residents of China: An Ecological Study.

作者信息

Ma Yunlei, Zhao Hanjun, Su Yinghao

机构信息

Department of Respiratory Medicine, Traditional Chinese Medicine Hospital of Hebei Province, Shijiazhuang, People's Republic of China.

Department of Respiratory Medicine, Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.

出版信息

J Asthma Allergy. 2023 Sep 6;16:951-960. doi: 10.2147/JAA.S422476. eCollection 2023.

DOI:10.2147/JAA.S422476
PMID:37700876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10493139/
Abstract

PURPOSE

The evidence for a causal relationship between high-level ozone (O) exposure and acute exacerbation of asthma among adults is limited, and the conclusions are less definitive.

PATIENTS AND METHODS

Here we collected the daily data on asthma cases, O exposure, and meteorological factors from 2010 to 2016 in Shijiazhuang, China. We investigated the risk of asthma exacerbation associated with high-level ozone exposure using a polynomial distributed lag model (PDLM). Using a generalized additive model (GAM), we estimated the interactive effects between O and other pollutants as well as meteorological factors on asthma exacerbation.

RESULTS

A total of 7270 patients with asthma were enrolled from 22 governmental hospitals in 13 counties. Each 10 μg/m increase in O concentration on the exacerbation of asthma was associated with a 1.92% (95% CI = 0.80-3.03%) higher risk of asthma exacerbation on day lag 7. The cumulative risk of O on asthma exacerbation increased by 18.9% (95% CI = 12.8-25.4%) on the 14th day. High consecutive levels of O increase the risk of asthma exacerbation, and the interactive effect of O and sulfur dioxide (SO) appears before the exacerbation onset.

CONCLUSION

These findings suggested that O should be an important risk factor for asthma exacerbation, and health benefits in reducing asthma exacerbation risk would be gained with continued efforts to improve the air quality in China.

摘要

目的

成人高水平臭氧（O）暴露与哮喘急性加重之间存在因果关系的证据有限，结论也不太明确。

患者与方法

我们收集了中国石家庄2010年至2016年哮喘病例、臭氧暴露及气象因素的每日数据。我们使用多项式分布滞后模型（PDLM）研究与高水平臭氧暴露相关的哮喘加重风险。使用广义相加模型（GAM），我们估计了臭氧与其他污染物以及气象因素对哮喘加重的交互作用。

结果

从13个县的22家公立医院招募了共7270例哮喘患者。臭氧浓度每增加10μg/m ，在滞后7天时哮喘加重风险就会增加1.92%（95%置信区间=0.80 - 3.03%）。在第14天，臭氧对哮喘加重的累积风险增加了18.9%（95%置信区间=12.8 - 25.4%）。连续高水平的臭氧会增加哮喘加重风险，并且臭氧与二氧化硫（SO）的交互作用在加重发作前就已出现。

结论

这些发现表明臭氧应该是哮喘加重一个重要的风险因素，持续努力改善中国空气质量将获得降低哮喘加重风险的健康益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4dc/10493139/1d5caac18884/JAA-16-951-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4dc/10493139/4b0479307312/JAA-16-951-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4dc/10493139/fec41b4a7f57/JAA-16-951-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4dc/10493139/fc00b2d9bc7c/JAA-16-951-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4dc/10493139/8ccbca428bc0/JAA-16-951-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4dc/10493139/13489ab00026/JAA-16-951-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4dc/10493139/1d5caac18884/JAA-16-951-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4dc/10493139/4b0479307312/JAA-16-951-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4dc/10493139/fec41b4a7f57/JAA-16-951-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4dc/10493139/fc00b2d9bc7c/JAA-16-951-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4dc/10493139/8ccbca428bc0/JAA-16-951-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4dc/10493139/13489ab00026/JAA-16-951-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4dc/10493139/1d5caac18884/JAA-16-951-g0006.jpg

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