Gao Xiang, Ren Chunzhen, Li Linyu, Zhao Huilin, Liu Kai, Zhuang Mengjie, Lv Xinfang, Zhi Xiaodong, Jiang Hugang, Chen Qilin, Zhao Xinke, Li Yingdong
School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, China.
Gansu Province Key Laboratory of Chinese Medicine for the Prevention and Treatment of Chronic Diseases, Lanzhou, China.
Front Pharmacol. 2023 Aug 28;14:1119224. doi: 10.3389/fphar.2023.1119224. eCollection 2023.
, a traditional Chinese herbal medicine and food with a long history of clinical application, is used to improve health conditions and treat various diseases. polysaccharides (HPS), flavonoids, saponins, and alkaloids, are the primary components of . HPS is the most important natural active ingredient of , which has many pharmacological effects. Currently, HPS exhibits significant promise in drug development for various ailments such as tumors, diabetes, cardiovascular diseases, Alzheimer's disease, and fibrosis. This review paper discusses the extraction, separation, and content determination techniques of HPS, along with the investigation of its chemical constituents. More importantly, we reviewed the anti-inflammatory pharmacological effects of HPS, such as inhibition of inflammatory factors and NF-κB signaling pathway; antitumor activity through apoptosis induction in tumor cells and blocking tumor cell proliferation and metastasis; antioxidant effects; regulation of various cytokines and immune cells; regulation of blood sugar levels, such as in type I and type II diabetes and in diabetic complications; improvement in symptoms of Alzheimer disease; anti-aging and anti-fibrosis properties; and improvement in cerebral ischemia-reperfusion injury. This review paper establishes the theoretical foundation for future studies on the structure, mechanism, and clinical use of HPS.
是一种具有悠久临床应用历史的传统中草药和食品，用于改善健康状况和治疗各种疾病。多糖（HPS）、黄酮类化合物、皂苷和生物碱是其主要成分。HPS是最重要的天然活性成分，具有多种药理作用。目前，HPS在肿瘤、糖尿病、心血管疾病、阿尔茨海默病和纤维化等各种疾病的药物开发中显示出巨大潜力。本文综述了HPS的提取、分离和含量测定技术，以及对其化学成分的研究。更重要的是，我们综述了HPS的抗炎药理作用，如抑制炎症因子和NF-κB信号通路；通过诱导肿瘤细胞凋亡和阻断肿瘤细胞增殖与转移发挥抗肿瘤活性；抗氧化作用；调节各种细胞因子和免疫细胞；调节血糖水平，如在I型和II型糖尿病及糖尿病并发症中；改善阿尔茨海默病症状；抗衰老和抗纤维化特性；以及改善脑缺血再灌注损伤。本文为今后对HPS的结构、作用机制和临床应用的研究奠定了理论基础。
