Du Yujiao, Li Jing, Qu Pengfei, Dang Shaonong
Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, People's Republic of China.
Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, 710003, People's Republic of China.
Int J Womens Health. 2023 Sep 6;15:1405-1415. doi: 10.2147/IJWH.S420206. eCollection 2023.
There remains a data gap on vitamin B and folate level in maternal and child populations. This study aimed to assess the status of vitamin B and folate in maternal serum (MS) and umbilical cord serum (UCS).
This was a planned secondary analysis of a case-control study. A total of 858 pregnant women during late pregnancy and their newborns in the hospitals of China were included. Maternal peripheral venous blood and neonatal umbilical cord blood were collected to determine serum vitamin B and folate concentration. Relationship of vitamin B or folate concentration between MS and UCS was assessed by a quantile regression model and the non-linear relationship between them was examined.
Nutritional status of serum folate was better than that of vitamin B. Prevalence of deficiency in MS vitamin B and folate was 73.4% and 14.2%, respectively and these figures were about 17.8% and 0.1% in UCS. Both vitamin B and folate levels in UCS were significantly higher than those in MS (vitamin B: 321.0 pg/mL vs 158.3 pg/mL, folate: 16.5 ng/mL vs 7.0 ng/mL, <0.001). The median UCS-MS ratio of vitamin B and folate was 2.0 (95% CI: 1.94-2.06) and 2.4 (95% CI: 2.30-2.53), respectively. The levels of folate and vitamin B in UCS increased nonlinearly with their increase in MS which presented an inverted U-shaped curve.
Deficiency in vitamin B and folate in the women during late pregnancy in China is prevalent. Nutritional status of the two vitamins in umbilical cord serum is correlated nonlinearly with that in maternal serum. Folic acid supplementation may be accompanied with vitamin B to improve status of vitamin B and folate during pregnancy.
母婴群体中维生素B和叶酸水平的数据仍存在差距。本研究旨在评估孕妇血清（MS）和脐带血血清（UCS）中维生素B和叶酸的状况。
这是一项对病例对照研究的计划二次分析。纳入了中国医院中858名晚期妊娠孕妇及其新生儿。采集孕妇外周静脉血和新生儿脐带血以测定血清维生素B和叶酸浓度。通过分位数回归模型评估MS和UCS之间维生素B或叶酸浓度的关系，并检验它们之间的非线性关系。
血清叶酸的营养状况优于维生素B。MS中维生素B和叶酸缺乏的患病率分别为73.4%和14.2%，而在UCS中这些数字分别约为17.8%和0.1%。UCS中维生素B和叶酸水平均显著高于MS（维生素B：321.0 pg/mL对158.3 pg/mL，叶酸：16.5 ng/mL对7.0 ng/mL，<0.001）。维生素B和叶酸的UCS-MS中位数比值分别为2.0（95%CI：1.94 - 2.06）和2.4（95%CI：2.30 - 2.53）。UCS中叶酸和维生素B的水平随着MS中它们的增加而非线性增加，呈现倒U形曲线。
中国晚期妊娠女性中维生素B和叶酸缺乏普遍存在。脐带血血清中这两种维生素的营养状况与孕妇血清中的营养状况呈非线性相关。补充叶酸时可能应同时补充维生素B以改善孕期维生素B和叶酸的状况。
