• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

针对新冠病毒变异株的纵向研究确定了与德尔塔毒株严重程度相关的转录活跃微生物（TAMs）。

Longitudinal study across SARS-CoV-2 variants identifies transcriptionally active microbes (TAMs) associated with Delta severity.

作者信息

Devi Priti, Kumari Pallawi, Yadav Aanchal, Tarai Bansidhar, Budhiraja Sandeep, Shamim Uzma, Pandey Rajesh

机构信息

Division of Immunology and Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi 110007, India.

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.

出版信息

iScience. 2023 Aug 29;26(10):107779. doi: 10.1016/j.isci.2023.107779. eCollection 2023 Oct 20.

DOI:10.1016/j.isci.2023.107779
PMID:37701571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10493601/
Abstract

Emergence of new SARS-CoV-2 VOCs jeopardize global vaccine and herd immunity safeguards. VOCs interactions with host microbiota might affect clinical course and outcome. This longitudinal investigation involving Pre-VOC and VOCs (Delta & Omicron) holo-transcriptome based nasopharyngeal microbiome at taxonomic levels followed by metabolic pathway analysis and integrative host-microbiome interaction. VOCs showed enrichment of with dominance of . Interestingly with superiority of and , were highlights of Delta VOC rather than Omicron. Common species comprising the core microbiome across all variants, reiterated the significance of in Delta, and its association with metabolic pathways enhancing inflammation in patients. Microbe-host gene correlation network revealed , , and modulating immune pathways, which might augment clinical severity in Delta. Importantly, opportunistic species of , , , and were abundant in Delta-mortality. The study establishes a functional association between elevated nasal pathobionts and dysregulated host response, particularly for Delta.

摘要

新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变异株的出现危及全球疫苗和群体免疫保障。变异株与宿主微生物群的相互作用可能会影响临床病程和结果。这项纵向研究涉及基于全转录组的SARS-CoV-2变异株出现前（Pre-VOC）和变异株（德尔塔和奥密克戎）鼻咽微生物群在分类水平上的情况，随后进行代谢途径分析以及宿主-微生物群相互作用的综合分析。变异株显示出[具体微生物名称1]的富集，以[具体微生物名称2]为主导。有趣的是，[具体微生物名称3]和[具体微生物名称4]的优势是德尔塔变异株而非奥密克戎变异株的突出特点。所有变异株中构成核心微生物群的常见物种，重申了[具体微生物名称5]在德尔塔变异株中的重要性，以及它与增强患者炎症的代谢途径的关联。微生物-宿主基因相关网络揭示了[具体基因1]、[具体基因2]和[具体基因3]调节免疫途径，这可能会增加德尔塔变异株的临床严重程度。重要的是，[具体微生物名称6]、[具体微生物名称7]、[具体微生物名称8]和[具体微生物名称9]等机会性物种在德尔塔变异株导致的死亡病例中大量存在。该研究建立了鼻腔致病共生菌增加与宿主反应失调之间的功能关联，特别是对于德尔塔变异株而言。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feea/10493601/8f5bf1282ec5/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feea/10493601/7161c243c16e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feea/10493601/3c62b893590b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feea/10493601/6445bf34736a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feea/10493601/81d7ec4a3ef3/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feea/10493601/f75159de6338/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feea/10493601/8f5bf1282ec5/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feea/10493601/7161c243c16e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feea/10493601/3c62b893590b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feea/10493601/6445bf34736a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feea/10493601/81d7ec4a3ef3/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feea/10493601/f75159de6338/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feea/10493601/8f5bf1282ec5/gr5.jpg

相似文献

1
Longitudinal study across SARS-CoV-2 variants identifies transcriptionally active microbes (TAMs) associated with Delta severity.针对新冠病毒变异株的纵向研究确定了与德尔塔毒株严重程度相关的转录活跃微生物（TAMs）。
iScience. 2023 Aug 29;26(10):107779. doi: 10.1016/j.isci.2023.107779. eCollection 2023 Oct 20.
2
Increased Abundance of Achromobacter xylosoxidans and Bacillus cereus in Upper Airway Transcriptionally Active Microbiome of COVID-19 Mortality Patients Indicates Role of Co-Infections in Disease Severity and Outcome.COVID-19 死亡患者上呼吸道转录活跃微生物组中阿氏假单胞菌和蜡样芽孢杆菌丰度增加表明合并感染在疾病严重程度和转归中的作用。
Microbiol Spectr. 2022 Jun 29;10(3):e0231121. doi: 10.1128/spectrum.02311-21. Epub 2022 May 17.
3
The Clinical Severity of COVID-19 Variants of Concern: Retrospective Population-Based Analysis.关注的 COVID-19 变异株的临床严重程度：回顾性基于人群的分析。
JMIR Public Health Surveill. 2024 Aug 27;10:e45513. doi: 10.2196/45513.
4
Comparison of SARS-CoV-2 variants of concern in primary human nasal cultures demonstrates Delta as most cytopathic and Omicron as fastest replicating.在原代人鼻腔培养物中比较关注的 SARS-CoV-2 变异株，表明德尔塔变异株具有最高的细胞病变效应，而奥密克戎变异株复制速度最快。
mBio. 2024 Apr 10;15(4):e0312923. doi: 10.1128/mbio.03129-23. Epub 2024 Mar 13.
5
Transcriptionally active nasopharyngeal commensals and opportunistic microbial dynamics define mild symptoms in the COVID 19 vaccination breakthroughs.转录活跃的鼻咽共生菌和机会性微生物动态定义了 COVID-19 突破性疫苗接种的轻微症状。
PLoS Pathog. 2023 Feb 17;19(2):e1011160. doi: 10.1371/journal.ppat.1011160. eCollection 2023 Feb.
6
Detection of SARS-CoV-2 in Saliva and Nasopharyngeal Swabs According to Viral Variants.根据病毒变异情况，在唾液和鼻咽拭子中检测 SARS-CoV-2。
Microbiol Spectr. 2022 Dec 21;10(6):e0213322. doi: 10.1128/spectrum.02133-22. Epub 2022 Nov 8.
7
Co-evolution of SARS-CoV-2 variants and host immune response trajectories underlie COVID-19 pandemic to epidemic transition.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变体与宿主免疫反应轨迹的共同进化是新冠疫情向地方性流行转变的基础。
iScience. 2023 Oct 27;26(12):108336. doi: 10.1016/j.isci.2023.108336. eCollection 2023 Dec 15.
8
A Meta-Analysis on the Immunogenicity of Homologous versus Heterologous Immunization Regimens against SARS-CoV-2 Beta, Delta, and Omicron BA.1 VoCs in Healthy Adults.健康成年人中针对新冠病毒贝塔、德尔塔和奥密克戎BA.1变异株的同源与异源免疫方案免疫原性的荟萃分析
J Microbiol Biotechnol. 2025 Feb 24;35:e2411059. doi: 10.4014/jmb.2411.11059.
9
Anamnestic humoral correlates of immunity across SARS-CoV-2 variants of concern.针对关切的 SARS-CoV-2 变异株的免疫的记忆体液相关性。
mBio. 2023 Aug 31;14(4):e0090223. doi: 10.1128/mbio.00902-23. Epub 2023 Aug 3.
10
Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta.暴露于新冠病毒变异株的单核细胞衍生巨噬细胞的转录组图谱揭示了由德尔塔驱动的免疫逃逸。
J Transl Med. 2025 Feb 4;23(1):151. doi: 10.1186/s12967-025-06158-2.

引用本文的文献

1
The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19.肠道微生物群与鼻咽微生物群组成之间的关系可以预测新冠肺炎的严重程度。
Elife. 2025 Feb 18;13:RP95292. doi: 10.7554/eLife.95292.
2
Metatranscriptomic insights into the dengue patient blood microbiome: Enhanced microbial diversity and metabolic activity in severe patients.宏转录组学揭示登革热患者血液微生物组：重症患者的微生物多样性和代谢活性增强。
PLoS Negl Trop Dis. 2024 Oct 17;18(10):e0012589. doi: 10.1371/journal.pntd.0012589. eCollection 2024 Oct.
3
Dual RNA-Seq reveals transcriptionally active microbes (TAMs) dynamics in the serum of dengue patients associated with disease severity.

本文引用的文献

1
Risk factors associated with length of hospital stay and medical expenses in pulmonary abscess patients: retrospective study.肺脓肿患者住院时间和医疗费用的相关风险因素：回顾性研究。
PeerJ. 2023 Apr 12;11:e15106. doi: 10.7717/peerj.15106. eCollection 2023.
2
Transcriptionally active nasopharyngeal commensals and opportunistic microbial dynamics define mild symptoms in the COVID 19 vaccination breakthroughs.转录活跃的鼻咽共生菌和机会性微生物动态定义了 COVID-19 突破性疫苗接种的轻微症状。
PLoS Pathog. 2023 Feb 17;19(2):e1011160. doi: 10.1371/journal.ppat.1011160. eCollection 2023 Feb.
3
Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors.
双RNA测序揭示了登革热患者血清中与疾病严重程度相关的转录活性微生物（TAM）动态变化。
Front Microbiol. 2023 Nov 30;14:1307859. doi: 10.3389/fmicb.2023.1307859. eCollection 2023.
严重 COVID-19 的风险因素：宿主、病毒和环境因素的综述。
Viruses. 2023 Jan 7;15(1):175. doi: 10.3390/v15010175.
4
Transcriptome analysis reveals increased abundance and diversity of opportunistic fungal pathogens in nasopharyngeal tract of COVID-19 patients.转录组分析揭示新冠病毒患者鼻咽部机会性真菌病原体丰度和多样性增加。
PLoS One. 2023 Jan 19;18(1):e0278134. doi: 10.1371/journal.pone.0278134. eCollection 2023.
5
SARS-CoV-2 variant biology: immune escape, transmission and fitness.SARS-CoV-2 变体生物学：免疫逃逸、传播和适应性。
Nat Rev Microbiol. 2023 Mar;21(3):162-177. doi: 10.1038/s41579-022-00841-7. Epub 2023 Jan 18.
6
Alterations in the nasopharyngeal microbiome associated with SARS-CoV-2 infection status and disease severity.鼻咽微生物组的改变与 SARS-CoV-2 感染状况和疾病严重程度有关。
PLoS One. 2022 Oct 14;17(10):e0275815. doi: 10.1371/journal.pone.0275815. eCollection 2022.
7
A comparative overview of SARS-CoV-2 and its variants of concern.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）及其关注变异株的比较概述。
Infez Med. 2022 Sep 1;30(3):328-343. doi: 10.53854/liim-3003-2. eCollection 2022.
8
Improved SARS-CoV-2 sequencing surveillance allows the identification of new variants and signatures in infected patients.改进的 SARS-CoV-2 测序监测可识别感染患者中的新变体和特征。
Genome Med. 2022 Aug 12;14(1):90. doi: 10.1186/s13073-022-01098-8.
9
Microbial Resistance to Antibiotics and Effective Antibiotherapy.微生物对抗生素的耐药性与有效的抗生素治疗
Biomedicines. 2022 May 12;10(5):1121. doi: 10.3390/biomedicines10051121.
10
Oral dysbiosis and its linkage with SARS-CoV-2 infection.口腔菌群失调及其与 SARS-CoV-2 感染的关联。
Microbiol Res. 2022 Aug;261:127055. doi: 10.1016/j.micres.2022.127055. Epub 2022 May 4.