Gavalov S M, Ivanova T A, Kaznacheeva L F, Smirnova L P, Slabuko P A
Farmakol Toksikol. 1986 Sep-Oct;49(5):27-9.
A spectrophotometric micromethod for determination of theophylline in the blood is proposed. Theophylline pharmacokinetics was studied by the method in 71 children with bronchial asthma. Doses and the number of administrations were selected individually for 45 patients under control of blood plasma theophylline concentration. Good clinical results were obtained.
提出了一种用于测定血液中茶碱的分光光度微量法。采用该方法对71例支气管哮喘患儿的茶碱药代动力学进行了研究。在血浆茶碱浓度监测下，为45例患者个体化选择剂量和给药次数。取得了良好的临床效果。
