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危险因素及其对重症急性胰腺炎合并急性胃肠损伤的交互作用。

Risk factors and their interactive effects on severe acute pancreatitis complicated with acute gastrointestinal injury.

作者信息

Chen Jian-Hui, Zhang Mei-Fen, Du Wen-Chao, Zhang Yan-An

机构信息

Emergency Department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China.

出版信息

World J Gastrointest Surg. 2023 Aug 27;15(8):1712-1718. doi: 10.4240/wjgs.v15.i8.1712.

DOI:10.4240/wjgs.v15.i8.1712
PMID:37701702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10494591/
Abstract

BACKGROUND

There are many risk factors for severe acute pancreatitis (SAP) complicated with acute gastrointestinal injury (AGI), but few reports on the interaction between these risk factors.

AIM

To analyze the risk factors for SAP complicated with AGI and their interactive effects.

METHODS

We selected 168 SAP patients admitted to our hospital between December 2019 and June 2022. They were divided into AGI group and non-AGI group according to whether AGI was present. Demographic data and laboratory test data were compared between the two groups. The risk factors for SAP with concomitant AGI were analyzed using multifactorial logistic regression, and an analysis of the interaction of the risk factors was performed.

RESULTS

The percentage of patients with multiple organ dysfunction syndrome, acute physiological and chronic health scoring system II (APACHE II) score, white blood cell count and creatinine (CRE) level was higher in the AGI group than in the non-AGI group. There was a statistically significant difference between the two groups ( < 0.05). Logistic regression analysis indicated that an APACHE II score > 15 and CRE > 100 µmol/L were risk factors for SAP complicating AGI. The interaction index of APACHE II score and CRE level was 3.123.

CONCLUSION

An APACHE II score > 15 and CRE level > 100 µmol/L are independent risk factors for SAP complicated with AGI, and there is a positive interaction between them.

摘要

背景

重症急性胰腺炎（SAP）合并急性胃肠损伤（AGI）有许多危险因素，但关于这些危险因素之间相互作用的报道较少。

目的

分析SAP合并AGI的危险因素及其交互作用。

方法

选取2019年12月至2022年6月我院收治的168例SAP患者。根据是否存在AGI将其分为AGI组和非AGI组。比较两组的人口统计学数据和实验室检查数据。采用多因素logistic回归分析SAP合并AGI的危险因素，并对危险因素的交互作用进行分析。

结果

AGI组多器官功能障碍综合征患者比例、急性生理与慢性健康评分系统II（APACHE II）评分、白细胞计数和肌酐（CRE）水平均高于非AGI组。两组间差异有统计学意义（<0.05）。logistic回归分析表明，APACHE II评分>15分和CRE>100µmol/L是SAP并发AGI的危险因素。APACHE II评分与CRE水平的交互指数为3.123。

结论

APACHE II评分>15分和CRE水平>100µmol/L是SAP合并AGI的独立危险因素，且二者存在正向交互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c29/10494591/d88066cd0c7e/WJGS-15-1712-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c29/10494591/d88066cd0c7e/WJGS-15-1712-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c29/10494591/d88066cd0c7e/WJGS-15-1712-g001.jpg

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