Goldanskii V I, Avetisov V A, Kuz'min V V
FEBS Lett. 1986 Oct 20;207(1):181-3. doi: 10.1016/0014-5793(86)80036-9.
This work discusses the question about the role of chiral purity (homochirality) of nucleotides in the formation of complementary replicas. A qualitative answer to this question can be obtained from molecular models constructed to simulate the chiral defect in the polynucleotidic chain. It shows the necessity of homochirality of nucleotides for the complementarity preservation. The necessity of the strong mirror-symmetry breaking in the abiogenic formation of the self-replicating oligonucleotide structures is discussed in the context of prebiological evolution.
这项工作探讨了核苷酸的手性纯度（同手性）在互补复制体形成中的作用问题。从构建的用于模拟多核苷酸链中手性缺陷的分子模型可以得到这个问题的定性答案。它表明核苷酸的同手性对于保持互补性是必要的。在生命起源前的进化背景下，讨论了在自复制寡核苷酸结构的非生物形成中强烈镜像对称破缺的必要性。
