Jiangxi Province Key Laboratory of Molecular Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Drug Deliv. 2023 Dec;30(1):2256495. doi: 10.1080/10717544.2023.2256495.
Magnetic Drug Targeting (MDT) is of particular interest to researchers because of its good loading efficiency, targeting accuracy, and versatile use in vivo. Cardiovascular Disease (CVD) is a global chronic disease with a high mortality rate, and the development of more precise and effective treatments is imminent. A growing number of studies have begun to explore the feasibility of MDT in CVD, but an up-to-date systematic summary is still lacking. This review discusses the current research status of MDT from guiding magnetic fields, magnetic nanocarriers, delivery channels, drug release control, and safety assessment. The current application status of MDT in CVD is also critically introduced. On this basis, new insights into the existing problems and future optimization directions of MDT are further highlighted.
磁靶向药物递送（MDT）因其良好的载药效率、靶向准确性和在体内的多功能应用而引起研究人员的特别关注。心血管疾病（CVD）是一种全球性的慢性疾病，死亡率较高，迫切需要开发更精确、更有效的治疗方法。越来越多的研究开始探索 MDT 在 CVD 中的可行性，但仍缺乏最新的系统总结。本综述从导向磁场、磁性纳米载体、输送通道、药物释放控制和安全性评估等方面讨论了 MDT 的当前研究现状。还批判性地介绍了 MDT 在 CVD 中的当前应用现状。在此基础上，进一步强调了 MDT 现有问题和未来优化方向的新见解。
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