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用光驱动后生动物衰老过程中的能量转导。

Using light to drive energy transduction in metazoan aging.

机构信息

Research Group Epigenetics, Metabolism, and Longevity, Research Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany.

Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany.

出版信息

Trends Biochem Sci. 2023 Nov;48(11):920-922. doi: 10.1016/j.tibs.2023.08.010. Epub 2023 Sep 11.

DOI:10.1016/j.tibs.2023.08.010
PMID:37704489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10592090/
Abstract

Mitochondrial dysfunction is a central hallmark of aging and energy transduction is a promising target for longevity interventions. New research suggests that interventions in how energy is transduced could benefit healthy longevity. Here, we propose using light as an alternative energy source to fuel mitochondria and increase metazoan lifespan.

摘要

线粒体功能障碍是衰老的核心标志，而能量转导是延长寿命干预的有前途的靶点。新的研究表明，干预能量转导的方式可能有益于健康长寿。在这里，我们提出用光作为替代能源来为线粒体供能，从而延长后生动物的寿命。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02f4/10592090/0938d82c9dff/nihms-1927057-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02f4/10592090/0938d82c9dff/nihms-1927057-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02f4/10592090/0938d82c9dff/nihms-1927057-f0001.jpg

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A plant-derived natural photosynthetic system for improving cell anabolism.植物来源的天然光合作用系统，用于改善细胞合成代谢。
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Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I.卵母细胞通过抑制复合物 I 来维持 ROS 自由的线粒体代谢。
Nature. 2022 Jul;607(7920):756-761. doi: 10.1038/s41586-022-04979-5. Epub 2022 Jul 20.
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Optical Control of CD8 T Cell Metabolism and Effector Functions.光学控制 CD8 T 细胞代谢和效应功能。
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