Department of Neurophysics, Phillips Universität Marburg, Marburg, Germany.
Center for Mind, Brain, and Behavior - CMBB, Philipps-Universität Marburg, Marburg, Germany & Justus-Liebig-Universität Giessen, Giessen, Germany.
Commun Biol. 2023 Sep 13;6(1):938. doi: 10.1038/s42003-023-05291-2.
Visual landmarks influence spatial cognition and behavior, but their influence on visual codes for action is poorly understood. Here, we test landmark influence on the visual response to saccade targets recorded from 312 frontal and 256 supplementary eye field neurons in rhesus macaques. Visual response fields are characterized by recording neural responses to various target-landmark combinations, and then we test against several candidate spatial models. Overall, frontal/supplementary eye fields response fields preferentially code either saccade targets (40%/40%) or landmarks (30%/4.5%) in gaze fixation-centered coordinates, but most cells show multiplexed target-landmark coding within intermediate reference frames (between fixation-centered and landmark-centered). Further, these coding schemes interact: neurons with near-equal target and landmark coding show the biggest shift from fixation-centered toward landmark-centered target coding. These data show that landmark information is preserved and influences target coding in prefrontal visual responses, likely to stabilize movement goals in the presence of noisy egocentric signals.
视觉地标会影响空间认知和行为，但它们对标定动作的视觉代码的影响还不太清楚。在这里，我们测试了地标对恒河猴 312 个额眼区和 256 个补充眼区神经元记录的眼跳目标视觉反应的影响。通过记录对各种目标地标组合的神经反应，然后用几个候选空间模型进行测试，来确定视觉反应场。总的来说，额眼区/补充眼区的反应场优先以凝视固定中心坐标编码眼跳目标（40%/40%）或地标（30%/4.5%），但大多数细胞在中间参考系（固定中心和地标中心之间）内显示出多路复用的目标地标编码。此外，这些编码方案相互作用：具有近乎相等的目标和地标编码的神经元，从以固定中心为目标编码向以地标中心为目标编码的转变最大。这些数据表明，地标信息在额前视觉反应中得到了保留，并影响了目标编码，可能在存在嘈杂的自我中心信号的情况下稳定运动目标。
