Wang Qian, Song Xiaoyue, Bi Yi, Zhu Haijing, Wu Xianfeng, Guo Zhengang, Liu Mei, Pan Chuanying
College of Animal Science and Technology, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Northwest A&F University, Yangling, Shaanxi, China.
Shaanxi Provincial Engineering and Technology Research Center of Cashmere Goats, Yulin University, Yulin, Shaanxi, China.
Front Vet Sci. 2023 Aug 29;10:1132833. doi: 10.3389/fvets.2023.1132833. eCollection 2023.
As a member of the SNX family, the () is initially identified as a myogenesis gene. Therefore, this study aimed to examine the polymorphism in the gene and its association with growth traits. In this study, we used an online platform to predict the structures of the protein and used quantitative real-time PCR to detect potential copy number variation (CNV) in Shaanbei white cashmere (SBWC) goats ( = 541), Guizhou black (GB) goats ( = 48), and Nubian (NB) goats ( = 39). The results showed that goat protein belonged to non-secretory protein. Then, five CNVs were detected, and their association with growth traits was analyzed. In SBWC goats, CNV1, CNV3, CNV4, and CNV5 were associated with chest width and body length ( < 0.05). Among them, the CNV1 individuals with gain and loss genotypes were superior to those individuals with a median genotype, but CNV4 and CNV5 of individuals with the median genotype were superior to those with the loss and gain genotypes. In addition, individuals with the gain genotype had superior growth traits in CNV3. In brief, this study suggests that the CNV of can be used as a molecular marker in goat breeding.
作为分选连接蛋白（SNX）家族的一员，（）最初被鉴定为一个肌生成基因。因此，本研究旨在检测该基因的多态性及其与生长性状的关联。在本研究中，我们使用在线平台预测该蛋白的结构，并采用定量实时PCR检测陕北白绒山羊（SBWC，n = 541）、贵州黑山羊（GB，n = 48）和努比亚山羊（NB，n = 39）中潜在的拷贝数变异（CNV）。结果表明，山羊该蛋白属于非分泌蛋白。随后，检测到5个CNV，并分析了它们与生长性状的关联。在陕北白绒山羊中，CNV1、CNV3、CNV4和CNV5与胸宽和体长相关（P < 0.05）。其中，CNV1的增益和缺失基因型个体优于杂合基因型个体，但CNV
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