Ruiz-Lopera Sebastián, Restrepo René, Cannon Taylor M, Villiger Martin, Bouma Brett E, Uribe-Patarroyo Néstor
Opt Lett. 2023 Sep 15;48(18):4765-4768. doi: 10.1364/OL.499051.
We present computational refocusing in polarization-sensitive optical coherence tomography (PS-OCT) to improve spatial resolution in the calculated polarimetric parameters and extend the depth-of-field in phase-unstable, fiber-based PS-OCT systems. To achieve this, we successfully adapted short A-line range phase-stability adaptive optics (SHARP), a computational aberration correction technique compatible with phase-unstable systems, into a Stokes-based PS-OCT system with inter-A-line polarization modulation. Together with the spectral binning technique to mitigate system-induced chromatic polarization effects, we show that computational refocusing improves image quality in tissue polarimetry of swine eye anterior segment ex vivo with PS-OCT. The benefits, drawbacks, and potential applications of computational refocusing in anterior segment imaging are discussed.
我们提出了偏振敏感光学相干断层扫描（PS-OCT）中的计算重聚焦方法，以提高计算出的偏振参数的空间分辨率，并扩展基于光纤的相位不稳定PS-OCT系统的景深。为实现这一目标，我们成功地将短A线范围相位稳定性自适应光学（SHARP）（一种与相位不稳定系统兼容的计算像差校正技术）应用于具有线间偏振调制的基于斯托克斯的PS-OCT系统。结合光谱分箱技术以减轻系统引起的色偏振效应，我们表明计算重聚焦可改善PS-OCT对猪眼前节离体组织进行偏振成像时的图像质量。本文还讨论了计算重聚焦在前节成像中的优点、缺点和潜在应用。
