金黄色葡萄球菌NCTC 8325中α-溶血素结构基因的染色体图谱定位。
Chromosomal map location of the alpha-hemolysin structural gene in Staphylococcus aureus NCTC 8325.
作者信息
Pattee P A
出版信息
Infect Immun. 1986 Nov;54(2):593-6. doi: 10.1128/iai.54.2.593-596.1986.
Abstract
The alpha-hemolysin structural gene, hly+, previously cloned, insertionally inactivated, and introduced into the chromosome by allele replacement (M.O. O'Reilly, J.C.S. De Azavedo, S. Kennedy, and T.J. Foster, Microb. Pathog. 1:125-138, 1986), was shown by protoplast fusion and transformation to be in the gene order purC-hly-uraB-omega[chr::Tn916]1101-thrB on the chromosome of Staphylococcus aureus NCTC 8325. This location is clearly distinct from that of the agr determinant, a regulatory gene affecting several extracellular proteins, including alpha-hemolysin, located between tmn and ilv.
摘要
先前已通过等位基因替换进行克隆、插入失活并导入染色体的α-溶血素结构基因hly⁺（M.O. 奥赖利、J.C.S. 德阿扎维多、S. 肯尼迪和T.J. 福斯特，《微生物致病机制》1:125 - 138，1986年），通过原生质体融合和转化表明，在金黄色葡萄球菌NCTC 8325染色体上，其基因顺序为purC - hly - uraB - omega[chr::Tn916]1101 - thrB。该位置与agr决定簇的位置明显不同，agr决定簇是一个影响多种细胞外蛋白（包括α-溶血素）的调控基因，位于tmn和ilv之间。
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