Whittaker J L, Walker R A, Varley J M
Int J Cancer. 1986 Nov 15;38(5):651-5. doi: 10.1002/ijc.2910380506.
We have examined 62 specimens of benign fibrocystic breast tissue, fibroadenomas, carcinomas and surrounding non-malignant tissue excised from 50 patients to determine the level of expression of 4 cellular oncogenes, c-myc, c-H-ras, c-K-ras, and c-N-ras. Our results demonstrate that in breast carcinoma the frequency and relative level of expression of these oncogenes are significantly greater than those found for benign breast tissue. However, some fibrocystic specimens having prominent hyperplastic features also exhibited enhanced oncogene expression. In view of the association between the increased frequency of carcinoma of the breast in women with a previous history of benign breast disease, it will be interesting to follow up donors of benign specimens to see if there is any relationship between the expression of oncogenes in such lesions and the development of carcinomas.
我们检测了从50例患者身上切除的62份乳腺良性纤维囊性组织、纤维腺瘤、癌组织及周围非恶性组织标本，以确定4种细胞癌基因c-myc、c-H-ras、c-K-ras和c-N-ras的表达水平。我们的结果表明，在乳腺癌中，这些癌基因的表达频率和相对水平显著高于良性乳腺组织。然而，一些具有显著增生特征的纤维囊性标本也表现出癌基因表达增强。鉴于既往有良性乳腺疾病史的女性患乳腺癌的频率增加之间的关联，随访良性标本的捐赠者，观察此类病变中癌基因的表达与癌症发生之间是否存在任何关系将是很有趣的。
