Adams S M, Sharp M G, Walker R A, Brammar W J, Varley J M
University/ICI Joint Laboratory, University of Leicester, UK.
Br J Cancer. 1992 Jan;65(1):65-71. doi: 10.1038/bjc.1992.12.
The human gene sequences encoding the translation-associated functions of alpha-subunit of elongation factor 1 (EF-1 alpha) and the ubiquitin carboxyl extension protein (HUBCEP80) have been isolated by differential cDNA screening, and found to have significantly higher levels of expression in fibroadenomas (benign) compared with carcinomas (malignant) of the breast. These data parallel our previous findings that the acidic ribosomal phosphoprotein P2 also has higher expression levels in the benign breast tumours (Sharp et al., 1990). In situ hybridisation has shown these genes to be expressed predominantly in the epithelium of breast tumours.
通过差异cDNA筛选，已分离出编码延伸因子1（EF-1α）α亚基翻译相关功能的人类基因序列以及泛素羧基延伸蛋白（HUBCEP80），并发现它们在乳腺纤维腺瘤（良性）中的表达水平明显高于乳腺癌（恶性）。这些数据与我们之前的发现一致，即酸性核糖体磷蛋白P2在良性乳腺肿瘤中也有较高的表达水平（Sharp等人，1990年）。原位杂交显示这些基因主要在乳腺肿瘤的上皮细胞中表达。
