Heilongjiang University of Chinese Medicine, Harbin, China.
First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
Front Endocrinol (Lausanne). 2023 Aug 29;14:1237260. doi: 10.3389/fendo.2023.1237260. eCollection 2023.
This study aims to evaluate the effect of acupuncture on the emotion domain and metabolic parameters of Chinese women with polycystic ovarian syndrome (PCOS) by secondary analysis of a randomized clinical trial, conducted from 6 July 2012 to 7 October 2015.
In this study, we investigated the effects of acupuncture (458 patients) and sham acupuncture (468 patients) on metabolic parameters, serum ions, and all quality-of-life scale scores related to PCOS. The quality of life of patients was evaluated using five relevant scales, operated by the research assistant, namely, PCOSQ, SF-36, and ChiQOL, as well as Zung-SAS and Zung-SDS. Metabolic parameters and serum ions were measured.
A reduction in acne score, AN, Hcy, and LDL-C, and an increase in the level of lipoprotein α, Apo A1, and Apo A1/Apo B were observed in the acupuncture group after 4 months' intervention after adjusting clomiphene and reproductive outcome (< 0.05). An increase in SF-36 total scores, RP and RE scores, ChiQOL total scores, and emotion domain scores was observed in the acupuncture group after 4 months' intervention, while PF and HT scores were decreased (adjusted < 0.05). Those same changes were observed in sham acupuncture. Meanwhile, the serum levels of Ca, K, and Cl were elevated in the acupuncture group after the interventions (adjusted < 0.005). There were no significant differences in HOMA-IR, MetS, FPG, FINS, HDL-C, TG, Apo B, and level of serum P, Mg, and Na. Also, no changes in BP, GH, VT, SF, physical form domain, and spirit domain were observed after treatment.
Acupuncture can improve not only the emotional changes in SF-36 scores and ChiQOL scores, but also lipid metabolism, implying that it may have a correlation between emotional change and lipid metabolism. Furthermore, acupuncture can also regulate the changes of serum Ca, K, and Cl.
ClinicalTrials.gov, identifier NCT01573858.
通过对 2012 年 7 月 6 日至 2015 年 10 月 7 日进行的一项随机临床试验的二次分析，评估针灸对中国多囊卵巢综合征（PCOS）女性情绪领域和代谢参数的影响。
在这项研究中，我们调查了针灸（458 例患者）和假针灸（468 例患者）对代谢参数、血清离子和所有与 PCOS 相关的生活质量量表评分的影响。通过研究助理操作的五个相关量表（即 PCOSQ、SF-36、ChiQOL、Zung-SAS 和 Zung-SDS）评估患者的生活质量。测量代谢参数和血清离子。
在调整克罗米酚和生殖结果后，针灸组在干预 4 个月后观察到痤疮评分、AN、Hcy 和 LDL-C 降低，脂蛋白α、Apo A1 和 Apo A1/Apo B 水平升高（<0.05）。在干预 4 个月后，针灸组 SF-36 总分、RP 和 RE 评分、ChiQOL 总分和情绪领域评分增加，而 PF 和 HT 评分降低（调整后<0.05）。假针灸组也观察到同样的变化。同时，针灸组干预后血清 Ca、K 和 Cl 水平升高（调整后<0.005）。HOMA-IR、MetS、FPG、FINS、HDL-C、TG、Apo B 和血清 P、Mg 和 Na 水平无显著差异。治疗后 BP、GH、VT、SF、形体域和精神域也无变化。
针灸不仅能改善 SF-36 评分和 ChiQOL 评分的情绪变化，还能改善脂代谢，提示其可能与情绪变化和脂代谢之间存在相关性。此外，针灸还可以调节血清 Ca、K 和 Cl 的变化。
ClinicalTrials.gov，标识符 NCT01573858。
