Bertolazzi Marília A, Genta Maria Luiza Nogueira Dias, Carvalho Filomena, Baracat Edmund C, Carvalho Jesus Paula
Department of Gynecologic Oncology, Universidade de São Paulo, São Paulo, BRA.
Department of Pathology, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, BRA.
Cureus. 2023 Aug 14;15(8):e43472. doi: 10.7759/cureus.43472. eCollection 2023 Aug.
Cervical cancer is one of the most frequent gynecological malignancies in Brazil, and most of the patients require pelvic radiotherapy as part of oncological treatment. Pelvic radiotherapy induces ovarian premature insufficiency in pre-menopausal women. This condition impacts the life quality and increases the risk of osteoporosis, obesity, cardiovascular, and neurodegenerative diseases in the middle and long term. Most of these patients have no access to hormonal replacement therapy. Techniques such as ovarian transposition have questionable results when aiming to preserve ovarian function. In this context, a promising alternative is the implantation of fresh ovarian tissue, outside the radiotherapy field, in the abdominal cavity (orthotopic implantation) or in other sites such as the forearm, breast, or subcutaneous tissue (heterotopic implantation). Here we report a successful case of autologous implantation of fresh ovarian tissue in the inner thigh of a young patient with advanced cervical cancer, who was a candidate for concurrent chemoradiotherapy.
宫颈癌是巴西最常见的妇科恶性肿瘤之一，大多数患者需要盆腔放疗作为肿瘤治疗的一部分。盆腔放疗会导致绝经前女性卵巢早衰。这种情况会影响生活质量，并在中长期增加骨质疏松、肥胖、心血管疾病和神经退行性疾病的风险。这些患者中的大多数无法获得激素替代疗法。诸如卵巢移位等技术在旨在保留卵巢功能时效果存疑。在此背景下，一种有前景的替代方法是将新鲜卵巢组织植入放疗区域外的腹腔（原位植入）或其他部位，如前臂、乳房或皮下组织（异位植入）。在此，我们报告一例年轻晚期宫颈癌患者自体新鲜卵巢组织植入大腿内侧成功的病例，该患者是同步放化疗的候选者。
