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卵巢移位与宫颈癌。

Ovarian transposition and cervical cancer.

机构信息

Department of Gynaecologic Oncology, Leeds Teaching Hospitals NHS Trust, Beckett Street, Harehills, Leeds, LS97TF, UK.

Tommy's National Centre for Miscarriage Research, Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham Women's Foundation NHS Trust, Heritage Building, Mindelsohn Way, Edgbaston, Birmingham, B15 2TH, UK.

出版信息

Best Pract Res Clin Obstet Gynaecol. 2021 Sep;75:37-53. doi: 10.1016/j.bpobgyn.2021.01.013. Epub 2021 Feb 26.

Abstract

Cervical cancer is the fourth most common female malignancy worldwide. As the focus of treatment is shifting towards balancing oncological outcomes with reproductive benefit, women are becoming increasingly aware of their fertility options. Cervical cancer is one of the primary malignancies where transposition of the ovaries may be indicated. Ovarian transposition should be performed in pre-menopausal women, undergoing pelvic irradiation to preserve ovarian function and prevent early menopause. The review discusses the available literature and synthesises a concise summary for gynaecologic oncology surgeons to counsel affected women. The paradoxical controversy, leading to its under use is acknowledged, due to the scarcity of published data with regard to functional outcomes, and the lack of clinical trials. In cervical cancer, ovarian transposition remains a safe fertility preservation (FP) option, which is associated with high ovarian function preservation, an acceptable rate of ovarian cysts and a negligible risk for metastases in the transposed ovaries.

摘要

宫颈癌是全球第四大常见的女性恶性肿瘤。随着治疗重点逐渐转向平衡肿瘤学结果和生殖益处,女性越来越关注自己的生育选择。卵巢移位术可能适用于宫颈癌等主要恶性肿瘤之一。对于接受盆腔放疗以保护卵巢功能和预防早绝经的绝经前妇女,应进行卵巢移位术。本文回顾了相关文献,并为妇科肿瘤外科医生提供了一份简明的总结,以便为受影响的女性提供咨询。由于关于功能结果的发表数据稀缺,以及缺乏临床试验,导致其使用不足,存在矛盾的争议,这一点得到了承认。在宫颈癌中,卵巢移位术仍然是一种安全的生育力保存(FP)选择,它与高卵巢功能保存、可接受的卵巢囊肿发生率和转移到移位卵巢的风险极低相关。

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