Al Ghaithi Istaqlal, Ahmed Bushra, Al Dughaishi Tamima, Al Riyami Nihal, Al Haddabi Rahma, Gowri Vaidyanathan
Obstetrics and Gynecology Residency Training Program, Oman Medical Specialty Board, Muscat, Oman.
Department of Obstetrics and Gynecology, Sultan Qaboos University Hospital, Muscat, Oman.
Oman Med J. 2023 Jul 31;38(4):e530. doi: 10.5001/omj.2023.90. eCollection 2023 Jul.
To evaluate the effect of COVID-19 severity on maternal, perinatal, and neonatal outcomes in pregnant women infected with SARS-CoV-2. We also aimed to assess the effect of medical comorbidities on the severity of COVID-19.
A retrospective cohort study was conducted on women who became infected with SARS-CoV-2 during pregnancy and delivered at Sultan Qaboos University Hospital, Oman, from 1 March 2020 to 31 December 2021.
A total of 118 pregnant women with COVID-19 and their 118 newborns were included in the study. Mean maternal age was 32.0 years, with 60.2% of women infected in the third trimester. The majority of the participants had mild symptoms. Eleven (9.3%) women had moderate infection needing inpatient care. Six (5.1%) with severe infection were admitted to intensive care unit. The chronic diseases among the participants were hypothyroidism, obesity, sickle cell disease, epilepsy, and diabetes. The mean gestational age at delivery was 37.0 weeks with 20.9% of women delivering by cesarean section out of whom 37.5% had moderate-to-severe COVID-19. The most common complications associated with COVID-19 severity were preterm labor (0.002), preeclampsia (0.002), and intrauterine fetal death (0.089). Of the total 118 newborns, 111 were singletons and six were twins. One fetus died and three singletons were lost to miscarriage. Placental histopathology conducted in 64 patients had no COVID-specific findings in most cases.
Most pregnant women with COVID-19 infections had mild symptoms. The majority of women with moderate-to-severe infection were admitted for COVID-19 pneumonia. There was no direct effect of COVID-19 severity in neonatal outcomes or placental histopathology changes.
评估新型冠状病毒肺炎（COVID-19）严重程度对感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的孕妇的孕产妇、围产期和新生儿结局的影响。我们还旨在评估合并症对COVID-19严重程度的影响。
对2020年3月1日至2021年12月31日期间在阿曼苏丹卡布斯大学医院感染SARS-CoV-2并分娩的孕妇进行了一项回顾性队列研究。
本研究共纳入118例感染COVID-19的孕妇及其118例新生儿。孕产妇平均年龄为32.0岁，60.2%的女性在孕晚期感染。大多数参与者症状较轻。11名（9.3%）女性感染程度为中度，需要住院治疗。6名（5.1%）感染严重的女性被收入重症监护病房。参与者中的慢性病包括甲状腺功能减退、肥胖、镰状细胞病、癫痫和糖尿病。分娩时的平均孕周为37.0周，20.9%的女性通过剖宫产分娩，其中37.5%患有中度至重度COVID-19。与COVID-19严重程度相关的最常见并发症是早产（0.002）、先兆子痫（0.002）和胎儿宫内死亡（0.089）。在118例新生儿中，111例为单胎，6例为双胞胎。1例胎儿死亡，3例单胎流产。64例患者进行的胎盘组织病理学检查在大多数情况下没有COVID特异性发现。
大多数感染COVID-19的孕妇症状较轻。大多数中度至重度感染的女性因COVID-19肺炎入院。COVID-19严重程度对新生儿结局或胎盘组织病理学变化没有直接影响。
