R&D Singapore, Essilor International, Singapore, Singapore.
Wenzhou Medical University-Essilor International Research Centre (WEIRC), Wenzhou Medical University, Wenzhou, China.
Ophthalmic Physiol Opt. 2024 Jan;44(1):206-213. doi: 10.1111/opo.13232. Epub 2023 Sep 15.
To evaluate eye growth of children wearing spectacle lenses with highly aspherical lenslets (HAL), slightly aspherical lenslets (SAL) and single-vision lenses (SVL) compared to eye growth patterns in non-myopes in Wenzhou, China.
The randomised trial had 170 myopic children (aged 8-13 years) randomly assigned to the HAL, SAL or SVL group. Normal eye growth was examined using 700 non-myopic schoolchildren (aged 7-9 years) in the Wenzhou Medical University-Essilor Progression and Onset of Myopia (WEPrOM) cohort study using logistic function models. Slow, normal and fast eye growth was defined as range of values <25th, 25th-75th and >75th percentiles, respectively.
The predicted upper limits of slow eye growth (25th percentile) among non-myopes aged 7-10 years and 11-13 years were 0.20-0.13 and 0.08-0.01 mm (after 2-year period; 0.37-0.33 and 0.29-0.14 mm), respectively, while the upper limits of normal eye growth (75th percentile) were 0.32-0.31 and 0.28-0.10 mm (after 2-year period; 0.58-0.55 and 0.50-0.24 mm), respectively. The 2-year trial had 157 children, 96 of whom wore their lenses full time (everyday ≥12 h/day). The mean 2-year axial length change for HAL, SAL and SVL was 0.34, 0.51 and 0.69 mm (0.28, 0.46 and 0.69 mm in full-time wear), respectively. Slow eye growth was found in 35%, 17% and 2% (44%, 29% and 3% in full-time wear); normal eye growth in 35%, 26% and 12% (44%, 32% and 9% in full-time wear) and fast eye growth in 30%, 57% and 86% (12%, 39% and 88% in full-time wear), respectively (p < 0.001).
The eye growth pattern in approximately 90% wearing HAL full time (compared with about 10% wearing SVL full time) was similar or slower than that of non-myopic children both after 1- and 2-year periods.
为了评估中国温州的儿童在佩戴高度非球面透镜（HAL）、轻度非球面透镜（SAL）和单焦点镜片（SVL）的眼镜后的眼生长情况，与非近视者的眼生长模式进行比较。
本随机试验纳入了 170 名近视儿童（年龄 8-13 岁），并将其随机分配至 HAL、SAL 或 SVL 组。使用温州医科大学-依视路近视进展与发病机制（WEPrOM）队列研究中的 700 名非近视学龄儿童（年龄 7-9 岁），使用逻辑函数模型来评估正常眼生长情况。将慢、正常和快眼生长分别定义为<25 百分位、25-75 百分位和>75 百分位的范围值。
在 7-10 岁和 11-13 岁的非近视儿童中，预测的 2 年期间（0.37-0.33 和 0.29-0.14mm）的慢眼生长（25 百分位）上限值分别为 0.20-0.13 和 0.08-0.01mm，而正常眼生长（75 百分位）上限值分别为 0.32-0.31 和 0.28-0.10mm（0.58-0.55 和 0.50-0.24mm）。在 2 年的试验中，共有 157 名儿童，其中 96 名全天（每天≥12 小时）佩戴其镜片。HAL、SAL 和 SVL 的 2 年轴向长度变化均值分别为 0.34、0.51 和 0.69mm（全天佩戴时分别为 0.28、0.46 和 0.69mm）。发现 35%、17%和 2%（全天佩戴时为 44%、29%和 3%）的儿童出现慢眼生长；35%、26%和 12%（全天佩戴时为 44%、32%和 9%）的儿童出现正常眼生长；30%、57%和 86%（全天佩戴时为 12%、39%和 88%）的儿童出现快眼生长（p<0.001）。
大约 90%的 HAL 全天佩戴者（与大约 10%的 SVL 全天佩戴者相比）的眼生长模式在 1 年和 2 年后与非近视儿童相似或较慢。
