Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wenzhou Medical University-Essilor International Research Center (WEIRC), Wenzhou Medical University, Wenzhou, China.
Br J Ophthalmol. 2023 Nov 22;107(12):1806-1811. doi: 10.1136/bjo-2022-321815.
Spectacle lenses with highly aspherical lenslets (HAL) and slightly aspherical lenslets (SAL) showed effective myopia control. This study was to investigate their effects on macular choroidal thickness (ChT) in myopic children.
Exploratory analysis from a 2-year, double-masked, randomised trial. 170 children aged 8-13 years with myopia between -0.75D and -4.75D, astigmatism of 1.50D or less, and anisometropia of 1.00D or less were recruited. Participants were randomly assigned in a 1:1:1 ratio to receive HAL, SAL or single vision spectacle lenses (SVL). The subfoveal, parafoveal and perifoveal ChT were evaluated every 6 months.
154 participants completed all examinations. The ChT showed significant changes over time in all three groups in all regions (all p<0.05). The ChTs continuously decreased in the SVL group (ranging from -20.75 (SD 22.34) μm to -12.18 (22.57) μm after 2 years in different regions). Compared with the SVL group, ChT in the SAL group decreased less (ranging from -16.49 (21.27) μm to -5.29 (18.15) μm). In the HAL group, ChT increased in the first year and then decreased in the second year (ranging from -0.30 (27.54) μm to 8.92 (23.97) μm after two years). The perifoveal ChT decreased less than the parafoveal ChT, and the superior region decreased the least.
The ChT of the macula decreased after 2 years of myopia progression with SVL. Wearing spectacle lenses with aspherical lenslets reduced or abolished the ChT thinning and HAL had a more pronounced effect.
ChiCTR1800017683.
高度非球面（HAL）和轻度非球面（SAL）的眼镜片在控制近视方面显示出了有效性。本研究旨在探讨其对近视儿童黄斑脉络膜厚度（ChT）的影响。
来自一项为期 2 年、双盲、随机试验的探索性分析。共招募了 170 名年龄在 8-13 岁之间、近视在-0.75D 至-4.75D 之间、散光 1.50D 或以下、屈光参差 1.00D 或以下的近视儿童。参与者以 1:1:1 的比例随机分配接受 HAL、SAL 或单光眼镜（SVL）。每 6 个月评估一次中心凹下、中心凹旁和旁中心凹的脉络膜厚度。
154 名参与者完成了所有检查。所有三组在所有区域的脉络膜厚度在所有时间均有显著变化（均 p<0.05）。SVL 组的脉络膜厚度持续下降（在不同区域，2 年后从-20.75（22.34）μm降至-12.18（22.57）μm）。与 SVL 组相比，SAL 组的脉络膜厚度下降较少（在不同区域，2 年后从-16.49（21.27）μm降至-5.29（18.15）μm）。HAL 组的脉络膜厚度在第一年增加，然后在第二年下降（在两年后从-0.30（27.54）μm增加到 8.92（23.97）μm）。旁中心凹的脉络膜厚度比中心凹旁的脉络膜厚度下降得少，上方区域的脉络膜厚度下降得最少。
使用 SVL 治疗近视进展 2 年后，黄斑区脉络膜厚度变薄。佩戴具有非球面透镜的眼镜可以减少或消除脉络膜厚度变薄，而 HAL 的效果更为显著。
ChiCTR1800017683。
