菲律宾移民女性的睡眠时间与代谢紊乱之间的关联：菲律宾女性饮食与健康研究（FiLWHEL）
Association between Sleep Duration and Metabolic Disorders among Filipino Immigrant Women: The Filipino Women's Diet and Health Study (FiLWHEL).
作者信息
Kim Hee Sun, Lee Heejin, Provido Sherlyn Mae P, Chung Grace H, Hong Sangmo, Yu Sung Hoon, Lee Jung Eun, Lee Chang Beom
机构信息
Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, Korea.
Research Institute of Human Ecology, Seoul National University, Seoul, Korea.
出版信息
J Obes Metab Syndr. 2023 Sep 30;32(3):224-235. doi: 10.7570/jomes22032. Epub 2023 Sep 18.
BACKGROUND
Sleep plays a complex role in metabolic regulation, and the underlying linkage has not been clearly defined. We investigated the association between sleep duration and metabolic disorders in Filipino immigrants in Korea.
METHODS
We analyzed 410 participants from the 2014 to 2016 baseline population of the Filipino Women's Diet and Health Study. Usual sleep duration was self-reported, and anthropometric parameters were measured directly. Blood glucose, lipid, and insulin levels were examined from fasting serum samples. We used general linear models to acquire least squares (LS) means and logistic regression models to calculate odds ratios to test the cross-sectional association between sleep duration and metabolic markers with 95% confidence intervals (CIs).
RESULTS
We found a statistically significant linear association between increased sleep duration and elevated triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). LS means (95% CI) of <5, 5-6, 7-8, and >8 hours of sleep were 81.74 (71.43 to 93.54), 85.15 (76.65 to 94.59), 86.33 (77.84 to 95.75), and 105.22 (88.07 to 125.71), respectively, for triglycerides ( trend=0.049) and 174.52 (165.02 to 184.57), 180.50 (172.79 to 188.55), 182.51 (174.83 to 190.53), and 190.16 (176.61 to 204.74), respectively, for total cholesterol ( trend= 0.042). For LDL-C, the LS means (95% CI) were 97.34 (88.80 to 106.71), 100.69 (93.73 to 108.18), 104.47 (97.35 to 112.10), and 109.43 (96.94 to 123.54), respectively ( trend=0.047). Statistical significance persisted after additional adjustment for body mass index. The association with triglycerides was limited to current alcohol drinkers ( interaction=0.048).
CONCLUSION
Longer sleep duration was associated with increased triglyceride, total cholesterol, and LDL-C levels. The association with triglycerides was more pronounced among moderate alcohol drinkers.
背景
睡眠在代谢调节中发挥着复杂的作用，其潜在联系尚未明确界定。我们调查了在韩国的菲律宾移民的睡眠时间与代谢紊乱之间的关联。
方法
我们分析了来自菲律宾女性饮食与健康研究2014年至2016年基线人群的410名参与者。通常的睡眠时间通过自我报告获得，人体测量参数直接测量。从空腹血清样本中检测血糖、血脂和胰岛素水平。我们使用一般线性模型获得最小二乘（LS）均值，并使用逻辑回归模型计算比值比，以检验睡眠时间与代谢标志物之间的横断面关联，并给出95%置信区间（CI）。
结果
我们发现睡眠时间增加与甘油三酯、总胆固醇和低密度脂蛋白胆固醇（LDL-C）升高之间存在统计学上显著的线性关联。睡眠时间<5小时、5 - 6小时、7 - 8小时和>8小时的甘油三酯LS均值（95%CI）分别为81.74（71.43至93.54）、85.15（76.65至94.59）、86.33（77.84至95.75）和105.22（88.07至125.71）（趋势 = 0.049），总胆固醇的LS均值分别为174.52（165.02至184.57）、180.50（172.79至188.55）、182.51（174.83至190.53）和190.16（176.61至204.74）（趋势 = 0.042）。对于LDL-C，LS均值（95%CI）分别为97.34（88.80至106.71）、100.69（93.73至108.18）、104.47（97.35至112.10）和109.43（96.94至123.54）（趋势 = 0.047）。在对体重指数进行额外调整后，统计学显著性仍然存在。与甘油三酯的关联仅限于当前饮酒者（交互作用 = 0.048）。
结论
较长的睡眠时间与甘油三酯、总胆固醇和LDL-C水平升高有关。在适度饮酒者中，与甘油三酯的关联更为明显。
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