Yang Dongwook, Solidum Jea Giezl Niedo, Park Dongsu
Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Center for Skeletal Biology, Baylor College of Medicine, Houston, TX, USA.
J Bone Metab. 2023 Aug;30(3):231-244. doi: 10.11005/jbm.2023.30.3.231. Epub 2023 Aug 31.
Dental pulp stem cells (DPSCs) have garnered significant interest in dental research for their unique characteristics and potential in tooth development and regeneration. While there were many studies to define their stem cell-like characteristics and osteogenic differentiation functions that are considered ideal candidates for regenerating damaged dental pulp tissue, how endogenous DPSCs respond to dental pulp injury and supply new dentin-forming cells has not been extensively investigated in vivo. Here, we review the recent progress in identity, function, and regulation of endogenous DPSCs and their clinical potential for pulp injury and regeneration. In addition, we discuss current advances in new mouse models, imaging techniques, and its practical uses and limitations in the analysis of DPSCs in pulp injury and regeneration in vivo.
牙髓干细胞（DPSCs）因其独特的特性以及在牙齿发育和再生方面的潜力，在牙科研究中引起了广泛关注。虽然有许多研究致力于确定其干细胞样特性和成骨分化功能，这些特性使其被视为再生受损牙髓组织的理想候选者，但内源性DPSCs如何响应牙髓损伤并提供新的牙本质形成细胞，在体内尚未得到广泛研究。在此，我们综述了内源性DPSCs在身份、功能和调控方面的最新进展，以及它们在牙髓损伤和再生中的临床潜力。此外，我们还讨论了新的小鼠模型、成像技术的当前进展，以及它们在体内牙髓损伤和再生中分析DPSCs的实际用途和局限性。
