Kwack Kyu Hwan, Lee Hyeon-Woo
Department of Dentistry, Graduate School, Kyung Hee University, Seoul, South Korea.
Department of Pharmacology, School of Dentistry, Graduate School, Institute of Oral Biology, Kyung Hee University, Seoul, South Korea.
Front Cell Dev Biol. 2022 Apr 11;10:857066. doi: 10.3389/fcell.2022.857066. eCollection 2022.
Dental caries is a common disease that not only destroys the rigid structure of the teeth but also causes pulp necrosis in severe cases. Once pulp necrosis has occurred, the most common treatment is to remove the damaged pulp tissue, leading to a loss of tooth vitality and increased tooth fragility. Dental pulp stem cells (DPSCs) isolated from pulp tissue exhibit mesenchymal stem cell-like characteristics and are considered ideal candidates for regenerating damaged dental pulp tissue owing to their multipotency, high proliferation rate, and viability after cryopreservation. Importantly, DPSCs do not elicit an allogeneic immune response because they are non-immunogenic and exhibit potent immunosuppressive properties. Here, we provide an up-to-date review of the clinical applicability and potential of DPSCs, as well as emerging trends in the regeneration of damaged pulp tissue. In addition, we suggest the possibility of using DPSCs as a resource for allogeneic transplantation and provide a perspective for their clinical application in pulp regeneration.
龋齿是一种常见疾病，它不仅会破坏牙齿的坚硬结构，在严重情况下还会导致牙髓坏死。一旦发生牙髓坏死，最常见的治疗方法是去除受损的牙髓组织，这会导致牙齿失去活力并增加牙齿的脆性。从牙髓组织中分离出的牙髓干细胞（DPSCs）具有间充质干细胞样特征，由于其多能性、高增殖率以及冷冻保存后的活力，被认为是再生受损牙髓组织的理想候选细胞。重要的是，DPSCs不会引发同种异体免疫反应，因为它们是非免疫原性的，并且具有强大的免疫抑制特性。在此，我们提供了关于DPSCs的临床适用性和潜力以及受损牙髓组织再生新趋势的最新综述。此外，我们提出了将DPSCs用作同种异体移植资源的可能性，并为其在牙髓再生中的临床应用提供了展望。
