Di Mitri Marco, Di Carmine Annalisa, Thomas Eduje, Iacobacci Giuseppe, Collautti Edoardo, D'Antonio Simone, Libri Michele, Gargano Tommaso, Lima Mario
From Pediatric Surgery Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Sviluppo Professionale e Implementazione della Ricerca nelle Professioni Sanitarie, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Plast Reconstr Surg Glob Open. 2023 Sep 14;11(9):e5244. doi: 10.1097/GOX.0000000000005244. eCollection 2023 Sep.
Acellular fish skin grafts (FSGs) are tissue-based products created by minimally processing the skin of the Atlantic cod (). The FSG is rich in omega-3 and facilitates tissue regeneration by supporting revascularization and ingrowth in the proliferation and remodeling phases of wound healing. FSG is structurally more similar to human skin than antiviral-processed skin substitutes such as amniotic membrane, and there are no known prion, bacterial, or viral diseases that can be transmitted from North-Atlantic cod to humans. The FSG is processed using a proprietary method that preserves the structure and lipid composition of the skin. FSG is CE marked, and US Food and Drug Administration cleared for multiple clinical applications in partial and full-thickness wounds. FSG is currently the only acellular dermal matrix product that does not originate from mammalian tissues. For this narrative review, Medline and UpToDate were used to include a total of 21 articles published from 2015 to 2022 about fish skin graft use. We also reported a case of a 7-year-old boy who underwent treatment with FSG for abdominal wall dehiscence at our department of pediatric surgery, IRCCS Sant'Orsola-Malpighi, Alma Mater Studiorum, University of Bologna, University Hospital of Bologna. FSG provides a valuable and sustainable treatment that improves wound healing in both adult and pediatric populations. We described the first application of an FSG for wound dehiscence of the abdominal wall in a pediatric patient, reporting how FSG was completely reabsorbed and improved the skin's repair.
脱细胞鱼皮移植物（FSG）是通过对大西洋鳕鱼的皮肤进行最少程度加工而制成的基于组织的产品。FSG富含ω-3，通过在伤口愈合的增殖和重塑阶段支持血管再生和向内生长来促进组织再生。与羊膜等经过抗病毒处理的皮肤替代品相比，FSG在结构上与人类皮肤更相似，并且没有已知的朊病毒、细菌或病毒疾病可从北大西洋鳕鱼传播给人类。FSG采用一种专有方法进行加工，该方法保留了皮肤的结构和脂质成分。FSG已获得CE标志，并且美国食品药品监督管理局批准其可用于部分和全层伤口的多种临床应用。FSG是目前唯一一种并非源自哺乳动物组织的脱细胞真皮基质产品。在本次叙述性综述中，我们使用Medline和UpToDate数据库，纳入了2015年至2022年发表的总共21篇关于鱼皮移植物使用的文章。我们还报告了一例7岁男孩的病例，该男孩在博洛尼亚大学阿尔玛·马特乌姆研究型大学附属医院IRCCS圣奥索拉 - 马尔皮基儿童医院接受了FSG治疗腹壁裂开的治疗。FSG提供了一种有价值且可持续的治疗方法，可改善成人和儿童人群的伤口愈合。我们描述了FSG在儿科患者腹壁伤口裂开中的首次应用，报告了FSG如何被完全吸收并改善了皮肤修复情况。
