Ramazanzadeh Nasim, Mahmoodi Nosrat O
Department of Organic Chemistry, Faculty of Science, University of Guilan, Rasht, Iran.
Turk J Chem. 2022 Feb 3;46(3):805-813. doi: 10.55730/1300-0527.3370. eCollection 2022.
A biocompatible nanocarrier system was prepared in this research through the reaction of calcium alginate (CA) with chitosan (CS). The structure of developed nanocarriers (CS-CA) was characterized by thermogravimetric analysis (TGA), Fourier transforms infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD) atomic force microscopy (AFM), and transmission electron microscopy (TEM). Swelling properties of CS-CA and CA, and their ability for loading and in vitro release of empagliflozin (EMP) were also investigated. The results showed the higher loading capacity of CS-CA compared to CA. For both nanocarriers, the drug release was higher at neutral pH (7.4 and 6.8) when compared to acidic pH (1.2). Despite the higher release of CA than CS-CA, the latter exhibited a favorable sustained drug release in all pH levels. As a result, CS-CA nanocarrier (EMP@CS-CANC) can be suggested as a new candidate for colon drug delivery of EMP.
本研究通过海藻酸钙（CA）与壳聚糖（CS）反应制备了一种生物相容性纳米载体系统。采用热重分析（TGA）、傅里叶变换红外（FT-IR）光谱、场发射扫描电子显微镜（FE-SEM）、X射线衍射（XRD）、原子力显微镜（AFM）和透射电子显微镜（TEM）对所制备的纳米载体（CS-CA）的结构进行了表征。还研究了CS-CA和CA的溶胀性能，以及它们对恩格列净（EMP）的负载能力和体外释放能力。结果表明，与CA相比，CS-CA具有更高的负载能力。对于这两种纳米载体，与酸性pH值（1.2）相比，在中性pH值（7.4和6.8）下药物释放更高。尽管CA的释放量高于CS-CA，但后者在所有pH值水平下均表现出良好的药物缓释性能。因此，CS-CA纳米载体（EMP@CS-CANC）可被认为是EMP结肠给药的新候选载体。
