Department of Chemistry, Faculty of Science, Ayatollah Boroujerdi University, Boroujerd, Iran.
Department of Chemistry, Faculty of Science, Ayatollah Boroujerdi University, Boroujerd, Iran.
Int J Biol Macromol. 2020 Aug 1;156:504-513. doi: 10.1016/j.ijbiomac.2020.04.068. Epub 2020 Apr 15.
This study focused on preparation of calcium alginate/single-walled carbon nanotube modified by glucose (CA/SWCNT-Gl) and its application as a carrier for the drug delivery system. This bionanocomposite was synthesized by using ultrasonication as a green method. Several quantitative ratios of the SWCNTs-Gl and the alginate were applied to the assessment of formulation for the curcumin entrapment. It was optimized by employing at 1:1 the SWCNTs-Gl to calcium alginate ratio. The structure of calcium alginate/SWCNTs-Gl was characterized by FTIR, XRD, SEM, EDX, TEM, DLS and TGA techniques. The nanocomposite as a carrier was examined for measurement of entrapment efficiency, loading capacity and release study for curcumin as a hydrophobic drug. The release of curcumin from carrier-curcumin have been measured in the pH 4.5 and pH 7.5 which revealed a fast release during the first hours followed by a gradual drug release. The outcomes indicated that the nanocomposite had great potential as a carrier and enabled for drug delivery systems. Further, the carrier displayed good antibacterial activity against Bacillus cereus and Escherichia coli. Likewise, better antibacterial activity of carrier-curcumin was observed in comparison with curcumin ones.
本研究集中于制备海藻酸钠/葡萄糖修饰的单壁碳纳米管（CA/SWCNT-Gl），并将其用作药物传递系统的载体。该生物纳米复合材料是通过超声处理这一绿色方法合成的。采用不同定量比例的 SWCNTs-Gl 和海藻酸钠来评估姜黄素包封的配方。通过采用 SWCNTs-Gl 与海藻酸钠的比例为 1:1 进行优化。通过傅里叶变换红外光谱（FTIR）、X 射线衍射（XRD）、扫描电子显微镜（SEM）、能谱分析（EDX）、透射电子显微镜（TEM）、动态光散射（DLS）和热重分析（TGA）技术对 CA/SWCNT-Gl 的结构进行了表征。纳米复合材料作为载体，用于测量姜黄素作为疏水性药物的包封效率、载药量和释放研究。在 pH 4.5 和 pH 7.5 下测量了载体-姜黄素中姜黄素的释放，结果表明在前几个小时内迅速释放，随后逐渐释放药物。结果表明，纳米复合材料具有作为载体的巨大潜力，并能够用于药物传递系统。此外，该载体对蜡状芽孢杆菌和大肠杆菌表现出良好的抗菌活性。同样，与姜黄素相比，载体-姜黄素的抗菌活性更好。
