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自组装肽/聚合物杂化纳米平台用于癌症免疫刺激治疗。

Self-assembled peptide/polymer hybrid nanoplatform for cancer immunostimulating therapies.

机构信息

Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Department of Pharmacology, Pharmacy and Pharmaceutical Technology, CiMUS Research Center and Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.

出版信息

Drug Deliv Transl Res. 2024 Feb;14(2):455-473. doi: 10.1007/s13346-023-01410-y. Epub 2023 Sep 18.

DOI:10.1007/s13346-023-01410-y
PMID:37721693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10761384/
Abstract

Integrating peptide epitopes in self-assembling materials is a successful strategy to obtain nanovaccines with high antigen density and improved efficacy. In this study, self-assembling peptides containing MAGE-A3/PADRE epitopes were designed to generate functional therapeutic nanovaccines. To achieve higher stability, peptide/polymer hybrid nanoparticles were formulated by controlled self-assembly of the engineered peptides. The nanoparticles showed good biocompatibility to both human red blood- and dendritic cells. Incubation of the nanoparticles with immature dendritic cells triggered immune effects that ultimately activated CD8 + cells. The antigen-specific and IgG antibody responses of healthy C57BL/6 mice vaccinated with the nanoparticles were analyzed. The in vivo results indicate a specific response to the nanovaccines, mainly mediated through a cellular pathway. This research indicates that the immunogenicity of peptide epitope vaccines can be effectively enhanced by developing self-assembled peptide-polymer hybrid nanostructures.

摘要

将肽表位整合到自组装材料中是获得具有高抗原密度和改善疗效的纳米疫苗的一种成功策略。在这项研究中，设计了包含 MAGE-A3/PADRE 表位的自组装肽，以生成功能性治疗性纳米疫苗。为了提高稳定性，通过工程化肽的控制自组装来制备肽/聚合物杂化纳米颗粒。这些纳米颗粒对人红细胞和树突状细胞均具有良好的生物相容性。纳米颗粒与未成熟树突状细胞孵育会引发免疫效应，最终激活 CD8+细胞。分析了用纳米颗粒接种的健康 C57BL/6 小鼠的抗原特异性和 IgG 抗体反应。体内结果表明，纳米疫苗具有特异性反应，主要通过细胞途径介导。这项研究表明，通过开发自组装肽-聚合物杂化纳米结构，可以有效增强肽表位疫苗的免疫原性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/dceb07c6d883/13346_2023_1410_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/b4809c255af4/13346_2023_1410_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/1c8b51905108/13346_2023_1410_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/dacce3a2ab99/13346_2023_1410_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/4e08aa270ab4/13346_2023_1410_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/078f64f19575/13346_2023_1410_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/dff6437381b6/13346_2023_1410_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/4b01bd29857f/13346_2023_1410_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/dceb07c6d883/13346_2023_1410_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/b4809c255af4/13346_2023_1410_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/1c8b51905108/13346_2023_1410_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/dacce3a2ab99/13346_2023_1410_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/4e08aa270ab4/13346_2023_1410_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/078f64f19575/13346_2023_1410_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/dff6437381b6/13346_2023_1410_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/4b01bd29857f/13346_2023_1410_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e67/10761384/dceb07c6d883/13346_2023_1410_Fig8_HTML.jpg

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4
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