Carpentier P, Aguilaniu F, Sarrot-Reynauld F, Devant O, Rousset J Y, Diamand J M, Massot C, Franco A
J Mal Vasc. 1986;11(3):237-41.
This study, involving the application of morphometric techniques to the conjunctival capillary bed in man, revealed a rarefaction of functional capillary density in patients with arteriolar sludge. Overall, in the population sample studied, capillary density and the degree of erythrocyte aggregation were correlated to erythrocyte sedimentation rate, despite the existence of discordant cases. These discordances were partially reduced by taking the hematocrit into account. Furthermore, multifactorial analysis of these parameters showed that hematocrit had an inhibitory action on erythrocyte aggregation which was more marked in vitro than in the microcirculation in vivo. By contrast, in vivo aggregation was more influenced by serum albumin levels. In both cases fibrinogen appeared to be the most significant pro-aggregant factor.
这项研究将形态测量技术应用于人体结膜毛细血管床，结果显示，患有小动脉血流淤滞的患者功能性毛细血管密度降低。总体而言，在所研究的人群样本中，尽管存在不一致的情况，但毛细血管密度和红细胞聚集程度与红细胞沉降率相关。通过考虑血细胞比容，这些不一致性部分减少。此外，对这些参数的多因素分析表明，血细胞比容对红细胞聚集有抑制作用，在体外比在体内微循环中更明显。相比之下，体内聚集受血清白蛋白水平的影响更大。在这两种情况下，纤维蛋白原似乎都是最显著的促聚集因子。
