Ansari Danya, Lakkimsetti Mohit, Olaleye Kehinde T, Bhullar Jaskomal Veer K, Shah Rida Z, Arisoyin Abimbola E, Nadeem Huzaifa, Sacal Slovik Sofia C, Habib Fatima Z, Abdin Zain U, Zia Ul Haq Muhammad
Psychiatry, Islamabad Medical and Dental College, Islamabad, PAK.
Internal Medicine, Mamata Medical College, Khammam, IND.
Cureus. 2023 Aug 18;15(8):e43702. doi: 10.7759/cureus.43702. eCollection 2023 Aug.
Borderline personality disorder (BPD) manifests as instability in mood, relationships, self-image, and behavior, representing a challenging mental health issue. This review scrutinizes genetic factors influencing BPD and the corresponding treatment outcomes. The primary objective of this narrative review is to illuminate the association between genetic factors and BPD treatment outcomes, discussing the potential of genetic testing for personalized therapy. The review is derived from observational and experimental studies on BPD, genetic factors, and psychotherapy from 2000 to 2023, sourced primarily through PubMed. Reviews and meta-analyses were excluded. Our review suggests that genetic factors account for 40-60% of BPD variation, with significant roles played by epigenetic alterations like DNA methylation and microRNAs, particularly in the context of childhood trauma. Gene-environment interactions are also vital for BPD's development. Treatments such as dialectical behavior therapy, mentalization-based therapy, and schema therapy have shown efficacy, with success variability possibly linked to genetic factors. However, existing research is constrained by recall bias, diverse methodologies, and limited sample sizes. Future research necessitates long-term follow-up, diverse populations, and controlled variables to enhance our comprehension of BPD treatment outcomes' genetic foundations. The review underlines the promise of personalized medicine in BPD treatment, driven by genetic insights.
边缘性人格障碍（BPD）表现为情绪、人际关系、自我形象和行为的不稳定，是一个具有挑战性的心理健康问题。本综述审视了影响BPD的遗传因素及相应的治疗结果。本叙述性综述的主要目的是阐明遗传因素与BPD治疗结果之间的关联，探讨基因检测用于个性化治疗的潜力。该综述源自2000年至2023年关于BPD、遗传因素和心理治疗的观察性和实验性研究，主要通过PubMed获取资料。综述和荟萃分析被排除在外。我们的综述表明，遗传因素占BPD变异的40%-60%，DNA甲基化和微小RNA等表观遗传改变发挥了重要作用，尤其是在童年创伤的背景下。基因-环境相互作用对BPD的发展也至关重要。辩证行为疗法、基于心理化的疗法和图式疗法等治疗方法已显示出疗效，成功的差异可能与遗传因素有关。然而，现有研究受到回忆偏倚、多样的方法和有限的样本量的限制。未来的研究需要长期随访、多样的人群和可控变量，以加强我们对BPD治疗结果遗传基础的理解。该综述强调了在遗传见解推动下，个性化医疗在BPD治疗中的前景。
