Department of Endocrinology, The Third Affiliated Hospital of Shanghai University, Wenzhou People's Hospital, Zhejiang, China.
Inquiry. 2023 Jan-Dec;60:469580231201022. doi: 10.1177/00469580231201022.
We aimed to investigate the role of the laboratory frailty index (LFI) in diabetic complications and incident disability in admitted older patients with type 2 diabetes mellitus (T2DM). We retrospectively collected the clinical data of older patients with T2DM from December 2018 to May 2020. Frailty was quantified using the LFI, which considers the accumulation of 27 items of abnormal laboratory outcomes. Univariate and multivariate analyses were performed to evaluate the relationship between LFI and diabetes-related adverse outcomes. In total, 293 consecutive older patients with T2DM were recruited for this study. According to the predefined LFI criteria, 110 (37.5%) participants were non-frail, 131 (44.7%) were prefrail, and 52 (17.8%) were frail. Univariate and multivariate analysis revealed that LFI was associated with the diabetic microangiopathy complications (odds ratio for prefrail [OR] 1.760, 95% confidence interval for prefrail [CI] 1.019-3.041, = .043; OR 4.667, 95% CI 2.012-10.826, < .001) and activities of daily living (ADL) disability (OR 2.323, 95% CI 1.209-4.463, = .011; OR 9.367, 95% CI 4.030-21.775, < .001), but not with the diabetic macroangiopathy complications and diabetic peripheral neuropathy. Frailty, as determined by the LFI, was proven to be an effective tool for the prediction of diabetic microangiopathy complications and ADL disability.
我们旨在探讨实验室衰弱指数（LFI）在患有 2 型糖尿病（T2DM）的住院老年患者的糖尿病并发症和新发残疾中的作用。我们回顾性收集了 2018 年 12 月至 2020 年 5 月间患有 T2DM 的老年患者的临床数据。使用 LFI 量化衰弱程度，该指数考虑了 27 项异常实验室结果的累积。进行单变量和多变量分析以评估 LFI 与糖尿病相关不良结局之间的关系。本研究共纳入 293 例连续的 T2DM 老年患者。根据预设的 LFI 标准，110 例（37.5%）患者无衰弱，131 例（44.7%）患者为衰弱前期，52 例（17.8%）患者为衰弱。单变量和多变量分析显示，LFI 与糖尿病微血管并发症相关（衰弱前期的比值比 [OR] 1.760，95%置信区间 [CI] 1.019-3.041， = .043；OR 4.667，95% CI 2.012-10.826， < .001）和日常生活活动（ADL）残疾（OR 2.323，95% CI 1.209-4.463， = .011；OR 9.367，95% CI 4.030-21.775， < .001），但与糖尿病大血管并发症和糖尿病周围神经病变无关。由 LFI 确定的衰弱被证明是预测糖尿病微血管并发症和 ADL 残疾的有效工具。
