Bilgin Satilmis, Aktas Gulali, Kurtkulagi Ozge, Atak Burcin M, Duman Tuba T
Department of Internal Medicine, Abant Izzet Baysal University Hospital, Golkoy, Bolu, 14280 Turkey.
J Diabetes Metab Disord. 2020 May 12;19(1):511-514. doi: 10.1007/s40200-020-00542-z. eCollection 2020 Jun.
We aimed to observe clinical and laboratory indices of the diabetic subjects who were either frail or not according to Edmonton frail score. We also aimed to study whether Edmonton frail score was correlated with metabolic and other parameters of the diabetic subjects.
Patients with T2DM visited our clinic were enrolled to the study and grouped as either frail or not frail according to the Edmonton score. Clinical and laboratory parameters of the groups were compared.
Serum triglyceride (p = 0.04), serum albumin (p = 0.006) and Glomerular Filtration Rate (GFR) (p = 0.01) were significantly lower, while fasting blood glucose (FBG) (p = 0.02), HDL cholesterol (p = 0.005) and glycated hemoglobin (HbA1c) (p = 0.04) were significantly higher in frail group compared to the not frail patients. Edmonton frail score was positively correlated with HbA1c, age, duration of T2DM, FBG, and negatively correlated with serum albumin and GFR levels.
We think that frailty is associated with poor glucose control in subjects with T2DM and better control of the disease may prevent or slow down the development of frailty, as well as microvascular complications in subjects with type 2 diabetes mellitus.
我们旨在观察根据埃德蒙顿衰弱评分判定为衰弱或非衰弱的糖尿病患者的临床和实验室指标。我们还旨在研究埃德蒙顿衰弱评分是否与糖尿病患者的代谢及其他参数相关。
将前来我们诊所就诊的2型糖尿病患者纳入研究，并根据埃德蒙顿评分分为衰弱组和非衰弱组。比较两组的临床和实验室参数。
与非衰弱患者相比，衰弱组的血清甘油三酯（p = 0.04）、血清白蛋白（p = 0.006）和肾小球滤过率（GFR）（p = 0.01）显著降低，而空腹血糖（FBG）（p = 0.02）、高密度脂蛋白胆固醇（p = 0.005）和糖化血红蛋白（HbA1c）（p = 0.04）显著升高。埃德蒙顿衰弱评分与HbA1c、年龄、2型糖尿病病程、FBG呈正相关，与血清白蛋白和GFR水平呈负相关。
我们认为，衰弱与2型糖尿病患者血糖控制不佳有关，更好地控制疾病可能预防或减缓衰弱的发展，以及2型糖尿病患者微血管并发症的发生。
