Tang Hongwei, Zhang Nan, Deng Jianchuan, Zhou Kang
Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Eur J Clin Invest. 2024 Jan;54(1):e14098. doi: 10.1111/eci.14098. Epub 2023 Sep 19.
To assess the prevalence trend and contributing factors of heart failure (HF) impairment with thalassemias at global, regional and national levels.
Data on HF impairment with thalassemias was collected from the Global Burden of Disease study. The absolute number and prevalence of the disease were systematically collected for each year, and the estimated annual percentage changes (EAPC) in HF impairment were calculated by gender, region and country to measure temporal trends.
Thalassemias have caused a significant global burden since 1990, and the case number of HF related to thalassemias has been steadily increasing. The highest case number of HF impairments with thalassemias is observed in China (7739 cases) and the highest prevalence is in Pakistan (1.61 per 100,000) currently. Besides, the middle sociodemographic index (SDI) region carries the highest burden of comorbid disease yet exhibits the most evident trend for improvement across the five regions (EAPC = -.98). The burden of thalassemias and comorbid HF is generally higher in males than females with the gender gap growing chasm in the future. Besides, the hotspots of HF impairment with thalassemias have gradually shifted to low SDI regions, though middle SDI regions still hold a relatively higher prevalence (.37 per 100,000) across different regions.
The burden of thalassemias and accompanying HF, as well as their temporal trends, vary greatly across countries and regions. These findings can improve understanding of these conditions and guide policymakers in developing appropriate policies to address disparities between countries.
在全球、区域和国家层面评估地中海贫血所致心力衰竭（HF）损伤的流行趋势及影响因素。
从全球疾病负担研究中收集地中海贫血所致HF损伤的数据。系统收集每年该疾病的绝对病例数和患病率，并按性别、区域和国家计算HF损伤的估计年度百分比变化（EAPC），以衡量时间趋势。
自1990年以来，地中海贫血已造成显著的全球负担，与地中海贫血相关的HF病例数一直在稳步增加。目前，中国观察到的地中海贫血所致HF损伤病例数最高（7739例），巴基斯坦的患病率最高（每10万人中1.61例）。此外，社会人口学指数（SDI）中等的区域合并症负担最高，但在五个区域中改善趋势最为明显（EAPC = -0.98）。地中海贫血和合并HF的负担总体上男性高于女性，且未来性别差距将不断扩大。此外，地中海贫血所致HF损伤的热点地区已逐渐转移到低SDI区域，不过在不同区域中，SDI中等的区域患病率仍相对较高（每10万人中0.37例）。
地中海贫血及伴发HF的负担及其时间趋势在不同国家和地区差异很大。这些发现有助于加深对这些情况的理解，并指导政策制定者制定适当政策以解决国家间的差异。
