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印度比哈尔邦瓦伊沙利地区不同性别和年龄组个体接触地下水中砷后的健康风险评估。

Health risk assessment upon exposure to groundwater arsenic among individuals of different sex and age groups of Vaishali district, Bihar (India).

作者信息

Kumar Pankaj, Khan Parimal Kumar, Kumar Amod

机构信息

Department of Zoology, Patna University, Patna 800005, India.

Department of Zoology, University of Delhi, New Delhi 110007, India.

出版信息

Toxicol Rep. 2025 Apr 9;14:102024. doi: 10.1016/j.toxrep.2025.102024. eCollection 2025 Jun.

Abstract

Availability of safe drinking water is one of the requirements for maintaining good health. Unfortunately, inhabitants of many nations suffer from adverse health effects due to the intake of arsenic-contaminated groundwater. The Vaishali district of Bihar (India) is the part of Ganga River Basin, a hotspot of arsenic contamination and hence, risk assessment among its individuals is highly pertinent. This study aimed to evaluate the extent of arsenic contamination in the ground waters of Bidupur block under Vaishali district, followed by an assessment of health risk, both non-cancer and cancer, within the arsenic-exposed adult females, adult males and children. Estimation of groundwater arsenic was done in 68 duplicate samples through an MQuant test kit (Merck, Germany). For this, Microsoft Office Excel and ArcGIS software were used as a tool. The results showed that only one-fourth of the groundwater samples exceeded the WHO permissible limit of arsenic with a high contamination factor. The total hazard index (HI), representing the non-cancer risk, was found above the threshold value (>1) among all individuals, which was high among the adults, more in adult females (3.21) than adult males (2.97), and low among the children (2.02). The cancer risk, expressed in terms of cancer index (CI), was also beyond the acceptable limit (10 to 10) among all sex and age groups, ranging from 0.91 × 10 to 1.45 × 10. Conclusively, arsenic was found to pose both high non-cancer and cancer risks in the population even at its low level due to long-term exposure.

摘要

获得安全饮用水是保持健康的必要条件之一。不幸的是,许多国家的居民因摄入受砷污染的地下水而遭受健康不良影响。印度比哈尔邦的瓦伊沙利区是恒河流域的一部分,是砷污染的热点地区,因此,对该地区居民进行风险评估非常有必要。本研究旨在评估瓦伊沙利区比杜布尔街区地下水中砷污染的程度,随后对砷暴露的成年女性、成年男性和儿童进行非癌症和癌症健康风险评估。通过MQuant测试试剂盒(德国默克公司)对68个重复样本中的地下水砷进行了测定。为此,使用Microsoft Office Excel和ArcGIS软件作为工具。结果表明,只有四分之一的地下水样本超过了世界卫生组织规定的砷允许限值,且污染因子较高。代表非癌症风险的总危害指数(HI)在所有个体中均高于阈值(>1),成年人中的该指数较高,成年女性(3.21)高于成年男性(2.97),儿童中的该指数较低(2.02)。以癌症指数(CI)表示的癌症风险在所有性别和年龄组中也超出了可接受限值(10至10),范围为0.91×10至1.45×10。总之,由于长期接触,即使砷含量较低,也发现其在人群中会造成较高的非癌症和癌症风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1940/12049810/f3c567ab0f3f/ga1.jpg

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