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三维打印生物材料在创伤愈合和假体中的应用新见解。

New Insights into the Applications of 3D-Printed Biomaterial in Wound Healing and Prosthesis.

机构信息

Amity Institute of Pharmacy, Amity University Uttar Pradesh Lucknow Campus, Lucknow, U.P., 226028, India.

Amity Institute of Pharmacy, Amity University Madhya Pradesh (AUMP), Gwalior, Madhya Pradesh, 474005, India.

出版信息

AAPS PharmSciTech. 2023 Sep 19;24(7):191. doi: 10.1208/s12249-023-02643-3.

Abstract

Recently three-dimensional bioprinting (3D-bioP) has emerged as a revolutionary technique for numerous biomedical applications. 3D-bioP has facilitated the printing of advanced and complex human organs resulting in satisfactory therapeutic practice. One of the important biomedical applications of 3D-bioP is in tissue engineering, wound healing, and prosthetics. 3D-bioP is basically aimed to restore the natural extracellular matrix of human's damage due to wounds. The relevant search was explored using various scientific database, viz., PubMed, Web of Science, Scopus, and ScienceDirect. The objective of this review is to emphasize interpretations from the pre-executed studies and to assess the worth of employing 3D-bioP in wound healing as well as prosthetics in terms of patient compliance, clinical outcomes, and economic viability. Furthermore, the benefits of applying 3D-bioP in wound healing over traditional methods have been covered along with the biocompatible biomaterials employed as bioinks has been discussion. Additionally, the review expands about the clinical trials in 3D-bioP field, showing promise of biomedical applicability of this technique with growing advancement in recent years.

摘要

最近,三维生物打印(3D-bioP)作为一种革命性的技术,已经在众多生物医学应用中崭露头角。3D-bioP 促进了先进而复杂的人类器官的打印,从而实现了令人满意的治疗实践。3D-bioP 的一个重要生物医学应用是在组织工程、伤口愈合和假肢领域。3D-bioP 的基本目的是恢复因伤口而受损的人体自然细胞外基质。使用各种科学数据库,如 PubMed、Web of Science、Scopus 和 ScienceDirect 进行了相关搜索。本综述的目的是强调从已执行研究中得出的解释,并评估在伤口愈合和假肢方面采用 3D-bioP 的价值,包括患者依从性、临床结果和经济可行性。此外,还讨论了应用 3D-bioP 在伤口愈合方面相对于传统方法的优势,以及用作生物墨水的生物相容性生物材料。此外,该综述还扩展了 3D-bioP 领域的临床试验,展示了该技术的生物医学应用前景,近年来随着技术的不断进步,该技术的应用也越来越广泛。

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