Department of Pediatrics, Gastroenterology and Nutrition, Institute of Pediatrics, Jagiellonian Universi-ty Medical College, Poland.
Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics, Institute of Pediatrics, Faculty of Medicine, Jagiellonian University, Medical College, Poland.
Pediatr Endocrinol Diabetes Metab. 2023;29(2):83-90. doi: 10.5114/pedm.2023.127273.
It is proven that life style modification (diet and physical exercises) have positive effect on the metabolic functions in pa-tients with obesity, even without significant weight reduction.
The objective of the present study was to check whether the intensive controlled lifestyle intervention (personalized diet modification and monitored, regular physical activity) may have positive impact on the concentration of irisin and chemerin in children with obesity.
Twenty children (mean age 8.9) were included in the prospective, cross-over study. They were randomly assigned to group A (with three months intensive intervention), and B (standard intervention). After three months, the groups were switched.
Mean irisin level increased significantly after the phase of intensive intervention (4.8 to 5.1 µg/ml; p = 0.03), regardless of whether the intervention was applied from the beginning (Group A) or after 3 months from the advice of healthy-lifestyle (Group B). A period without intensive monitoring was associated with a significant reduction of irisin level. For chemerin in the group A (starting from intensive intervention) mean level decreased after the phase of intensive intervention (65.8 to 57.0 ng/ml), and then increased to 67 ng/ml during the standard intervention. In the group B after the standard intervention period chemerin level increased 67.5 to 68.8 ng/ml (p = 0.03), and then after introduction the intensive intervention de-creased to 63.7 ng/ml.
Personalized diet modification and regular, daily exercises may positively influence on the levels of irisin and chemerin.
生活方式的改变（饮食和体育锻炼）已被证实对肥胖患者的代谢功能有积极影响，即使体重没有明显减轻也是如此。
本研究的目的是检查强化的生活方式干预（个性化饮食调整和监测、定期体育活动）是否对肥胖儿童的鸢尾素和趋化素浓度有积极影响。
20 名儿童（平均年龄 8.9 岁）被纳入前瞻性交叉研究。他们被随机分配到 A 组（进行三个月的强化干预）和 B 组（标准干预）。三个月后，两组进行了交换。
无论强化干预是从一开始（A 组）还是在健康生活方式建议 3 个月后（B 组）应用，鸢尾素水平在强化干预阶段后均显著升高（4.8 至 5.1 µg/ml；p = 0.03）。没有强化监测的时期与鸢尾素水平的显著下降相关。对于 A 组中的趋化素（从强化干预开始），在强化干预阶段后平均水平下降（65.8 至 57.0 ng/ml），然后在标准干预期间增加至 67 ng/ml。在 B 组中，标准干预期后，趋化素水平增加至 67.5 至 68.8 ng/ml（p = 0.03），然后在引入强化干预后降至 63.7 ng/ml。
个性化饮食调整和规律、日常运动可能会对鸢尾素和趋化素水平产生积极影响。
