miRNA 表达与伊拉克男性特发性不育风险的关联。
Association between microRNA expression and risk of male idiopathic infertility in Iraq.
机构信息
Al-Qadisiyah University, College of Medicine, Department of Medical Microbiology - Diwaniya, Iraq.
Directorate of Education Al-Muthanna, Ministry of Education - Baghdad, Iraq.
出版信息
Rev Assoc Med Bras (1992). 2023 Sep 18;69(9):e20230341. doi: 10.1590/1806-9282.20230341. eCollection 2023.
OBJECTIVE
The World Health Organization defines infertility as the inability to get pregnant after 12 months of unprotected sexual activity. This study was conducted to estimate the levels of gene expression for two mature miRNAs (i.e., miR-122 and miR-34c-5p) to evaluate susceptibility to male infertility.
METHODS
This study included 50 male patients with idiopathic infertility who were admitted to hospital from the period November 2021 to May 2022 and another group consisting of 50 apparently healthy individuals used as controls.
RESULTS
miR-122 level was significantly highest in azoospermia and followed by oligospermia, 39.22 (31.88) versus 37.34 (20.45), respectively. In addition, there was a very significant difference in miR-34c-5p levels between the study groups (p<0.05).
CONCLUSION
Two miRNAs, namely, miR-34c-5p and miR-122, can be used as predictive and diagnostic biomarkers for infertility.
目的
世界卫生组织将不孕定义为在无保护性行为 12 个月后仍无法怀孕。本研究旨在评估两种成熟 miRNA（即 miR-122 和 miR-34c-5p）的基因表达水平，以评估男性不育的易感性。
方法
本研究纳入了 2021 年 11 月至 2022 年 5 月期间因特发性不孕住院的 50 名男性患者和另外 50 名作为对照组的健康个体。
结果
miR-122 水平在无精子症中最高，其次是少精子症，分别为 39.22（31.88）和 37.34（20.45）。此外，两组间 miR-34c-5p 水平存在非常显著差异（p<0.05）。
结论
两种 miRNA，即 miR-34c-5p 和 miR-122，可以作为不孕的预测和诊断生物标志物。
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