变心：心力衰竭中小非编码 RNA 的表观转录组学。
Change of Heart: the Epitranscriptome of Small Non-coding RNAs in Heart Failure.
机构信息
Department of Surgery, Leiden University Medical Center, D6-P, PO Box 9600, 2300 RC, Leiden, the Netherlands.
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.
出版信息
Curr Heart Fail Rep. 2022 Oct;19(5):255-266. doi: 10.1007/s11897-022-00561-2. Epub 2022 Jul 25.
PURPOSE OF REVIEW
Small non-coding RNAs regulate gene expression and are highly implicated in heart failure. Recently, an additional level of post-transcriptional regulation has been identified, referred to as the epitranscriptome, which encompasses the body of post-transcriptional modifications that are placed on RNA molecules. In this review, we summarize the current knowledge on the small non-coding RNA epitranscriptome in heart failure.
RECENT FINDINGS
With the rise of new methods to study RNA modifications, epitranscriptome research has begun to take flight. Over the past 3 years, the number of publications on the epitranscriptome in heart failure has significantly increased, and we expect many more highly relevant publications to come out over the next few years. Currently, at least six modifications on small non-coding RNAs have been investigated in heart failure-relevant studies, namely N6-adenosine, N5-cytosine and N7-guanosine methylation, 2'-O-ribose-methylation, adenosine-to-inosine editing, and isomiRs. Their potential role in heart failure is discussed.
目的综述
小非编码 RNA 调节基因表达，并高度参与心力衰竭。最近，已经确定了另一种转录后调控水平，称为表观转录组，它包含了对 RNA 分子进行的各种转录后修饰。在这篇综述中，我们总结了心力衰竭中小非编码 RNA 表观转录组的最新知识。
最新发现
随着研究 RNA 修饰的新方法的出现，表观转录组研究开始兴起。在过去的 3 年中，心力衰竭中关于表观转录组的出版物数量显著增加，我们预计在未来几年内还会有更多高度相关的出版物问世。目前，至少有六种小非编码 RNA 的修饰已在与心力衰竭相关的研究中进行了研究，即 N6-腺嘌呤、N5-胞嘧啶和 N7-鸟嘌呤甲基化、2'-O-核糖甲基化、腺苷到肌苷编辑和同工型。讨论了它们在心力衰竭中的潜在作用。
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