电子尼古丁传送系统使用与中风风险之间的关联：对1,024,401名参与者的荟萃分析
Association between electronic nicotine delivery systems use and risk of stroke: a meta-analysis of 1,024,401 participants.
作者信息
Awad Kamal, Mohammed Maged, Martin Seth S, Banach Maciej
机构信息
Faculty of Medicine, Zagazig University, Zagazig, El-Sharkia, Egypt.
Primary Health Care Centers, Health Insurance Organization, El-Sharkia, Egypt.
出版信息
Arch Med Sci. 2023 Aug 27;19(5):1538-1540. doi: 10.5114/aoms/171473. eCollection 2023.
INTRODUCTION
To evaluate the relationship between electronic nicotine delivery systems (ENDS) use and the risk of stroke when compared to non-smokers.
METHODS
A comprehensive search was conducted until June 15, 2023. We included observational studies that assessed association of current or former usage of ENDS with risk of stroke compared with non-smokers, reported the risk estimate as odds ratio (OR) or hazard ratio (HR) and were adjusted for possible confounders.
RESULTS
6 studies with 1,024,401 participants were included in our analysis. ENDS use was associated with a significant increased risk of stroke (OR = 1.52; 95% CI: 1.17-1.97) compared with non-users. A non-significant association was found between former ENDS use and risk of stroke (OR = 1.03; 95% CI: 0.87-1.21).
CONCLUSIONS
The ENDS usage appears to be associated with a higher risk of stroke compared to non-use, whereas there was no association between former ENDS use and the risk of stroke.
引言
与不吸烟者相比，评估使用电子尼古丁传送系统（ENDS）与中风风险之间的关系。
方法
截至2023年6月15日进行了全面检索。我们纳入了观察性研究，这些研究评估了当前或以前使用ENDS与不吸烟者相比的中风风险关联，将风险估计报告为比值比（OR）或风险比（HR），并对可能的混杂因素进行了调整。
结果
我们的分析纳入了6项研究，共1,024,401名参与者。与未使用者相比，使用ENDS与中风风险显著增加相关（OR = 1.52；95%置信区间：1.17 - 1.97）。以前使用ENDS与中风风险之间未发现显著关联（OR = 1.03；95%置信区间：0.87 - 1.21）。
结论
与不使用相比，使用ENDS似乎与更高的中风风险相关，而以前使用ENDS与中风风险之间没有关联。
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