Helen Ward, Christina Atchison, Matthew Whitaker, Bethan Davies, Deborah Ashby, Marc Chadeau-Hyam, Steven Riley, and Paul Elliott are with the School of Public Health, Imperial College London, UK. Ara Darzi is with the Institute of Global Health Innovation, Imperial College London. Christl A. Donnelly is with the Department of Statistics, University of Oxford, Oxford, UK. Wendy Barclay and Graham S. Cooke are with the Department of Infectious Disease, Imperial College London.
Am J Public Health. 2023 Nov;113(11):1201-1209. doi: 10.2105/AJPH.2023.307381. Epub 2023 Sep 21.
The UK Department of Health and Social Care funded the REal-time Assessment of Community Transmission-2 (REACT-2) study to estimate community prevalence of SARS-CoV-2 IgG (immunoglobulin G) antibodies in England. We obtained random cross-sectional samples of adults from the National Health Service (NHS) patient list (near-universal coverage). We sent participants a lateral flow immunoassay (LFIA) self-test, and they reported the result online. Overall, 905 991 tests were performed (28.9% response) over 6 rounds of data collection (June 2020-May 2021). We produced weighted estimates of LFIA test positivity (validated against neutralizing antibodies), adjusted for test performance, at local, regional, and national levels and by age, sex, and ethnic group and area-level deprivation score. In each round, fieldwork occurred over 2 weeks, with results reported to policymakers the following week. We disseminated results as preprints and peer-reviewed journal publications. REACT-2 estimated the scale and variation in antibody prevalence over time. Community self-testing and -reporting produced rapid insights into the changing course of the pandemic and the impact of vaccine rollout, with implications for future surveillance. ( 2023;113(11):1201-1209. https://doi.org/10.2105/AJPH.2023.307381).
英国卫生部和社会保障部资助了实时评估社区传播-2（REACT-2）研究，以估计英格兰社区中 SARS-CoV-2 IgG（免疫球蛋白 G）抗体的流行率。我们从国民保健制度（NHS）患者名单中随机抽取了成年横断面样本（几乎涵盖所有人群）。我们向参与者发送了侧向流动免疫测定（LFIA）自检，他们在线报告结果。在 6 轮数据收集（2020 年 6 月至 2021 年 5 月）中，共进行了 905991 次测试（28.9%的响应率）。我们根据中和抗体对 LFIA 测试阳性率进行了加权估计（经过测试性能调整），并按地区、区域和国家以及年龄、性别和族裔群体以及地区贫困评分进行了调整。在每一轮中，实地工作持续两周，结果在下周报告给政策制定者。我们通过预印本和同行评审期刊出版物传播结果。REACT-2 估计了抗体流行率随时间的规模和变化。社区自我检测和报告迅速洞察了大流行的变化过程和疫苗推出的影响，对未来的监测具有重要意义。（2023；113(11):1201-1209. https://doi.org/10.2105/AJPH.2023.307381）。
