School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India.
Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
Int J Biol Macromol. 2023 Dec 31;253(Pt 4):126951. doi: 10.1016/j.ijbiomac.2023.126951. Epub 2023 Sep 19.
Public health globally faces significant risks from conditions like acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and various inflammatory lung disorders. The NF-κB signaling system partially controls lung inflammation, immunological responses, and remodeling. Non-coding RNAs (lncRNAs) are crucial in regulating gene expression. They are increasingly recognized for their involvement in NF-κB signaling and the development of inflammatory lung diseases. Disruption of lncRNA-NF-κB interactions is a potential cause and resolution factor for inflammatory respiratory conditions. This study explores the therapeutic potential of targeting lncRNAs and NF-κB signaling to alleviate inflammation and restore lung function. Understanding the intricate relationship between lncRNAs and NF-κB signaling could offer novel insights into disease mechanisms and identify therapeutic targets. Regulation of lncRNAs and NF-κB signaling holds promise as an effective approach for managing inflammatory lung disorders. This review aims to comprehensively analyze the interaction between lncRNAs and the NF-κB signaling pathway in the context of inflammatory lung diseases. It investigates the functional roles of lncRNAs in modulating NF-κB activity and the resulting inflammatory responses in lung cells, focusing on molecular mechanisms involving upstream regulators, inhibitory proteins, and downstream effectors.
全球公共卫生面临着严重的风险，如急性呼吸窘迫综合征（ARDS）、慢性阻塞性肺疾病（COPD）和各种炎症性肺部疾病。NF-κB 信号系统部分控制着肺部炎症、免疫反应和重塑。非编码 RNA（lncRNA）在调控基因表达中起着至关重要的作用。它们越来越多地被认为参与 NF-κB 信号和炎症性肺部疾病的发展。lncRNA-NF-κB 相互作用的破坏是炎症性呼吸疾病的潜在原因和解决因素。本研究探讨了靶向 lncRNA 和 NF-κB 信号以减轻炎症和恢复肺功能的治疗潜力。深入了解 lncRNA 和 NF-κB 信号之间的复杂关系可以为疾病机制提供新的见解，并确定治疗靶点。lncRNA 和 NF-κB 信号的调节有望成为治疗炎症性肺部疾病的有效方法。本综述旨在全面分析炎症性肺部疾病中 lncRNA 与 NF-κB 信号通路之间的相互作用。它研究了 lncRNA 在调节 NF-κB 活性和肺细胞中炎症反应方面的功能作用，重点关注涉及上游调节剂、抑制蛋白和下游效应物的分子机制。
