用于大脑的 PET 报告系统。
PET reporter systems for the brain.
机构信息
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.
出版信息
Trends Neurosci. 2023 Nov;46(11):941-952. doi: 10.1016/j.tins.2023.08.007. Epub 2023 Sep 19.
Positron emission tomography (PET) can be used as a noninvasive method to longitudinally monitor and quantify the expression of proteins in the brain in vivo. It can be used to monitor changes in biomarkers of mental health disorders, and to assess therapeutic interventions such as stem cell and molecular genetic therapies. The utility of PET monitoring depends on the availability of a radiotracer with good central nervous system (CNS) penetration and high selectivity for the target protein. This review evaluates existing methods for the visualization of reporter proteins and/or protein function using PET imaging, focusing on engineered systems, and discusses possible approaches for future success in the development of high-sensitivity and high-specificity PET reporter systems for the brain.
正电子发射断层扫描（PET）可用作一种非侵入性方法，用于在体内对大脑中蛋白质的表达进行纵向监测和定量。它可以用于监测精神健康障碍的生物标志物的变化，并评估治疗干预措施，如干细胞和分子遗传学疗法。PET 监测的效用取决于是否有具有良好中枢神经系统（CNS）穿透性和对目标蛋白高选择性的示踪剂。本综述评估了使用 PET 成像对报告蛋白和/或蛋白功能进行可视化的现有方法，重点介绍了工程系统，并讨论了未来在开发高灵敏度和高特异性用于大脑的 PET 报告系统方面取得成功的可能方法。
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