Toomasian J M, Schneiderman G, DeSmet G M, Bartlett R H
J Thorac Cardiovasc Surg. 1986 Nov;92(5):936-43.
A new autotransfusion device was evaluated in dogs. The device uses citrate phosphate dextrose as the blood anticoagulant and automatically delivers the agent in a ratio approximating that found in banked blood. Bleeding, aspiration, and autotransfusion of approximately 3 estimated blood volumes produced small changes in hematologic and coagulation studies. Blood electrolytes stayed within normal ranges. Activated clotting times stayed within normal range after autotransfusion of 2 blood volumes but increased slightly after 3 blood volume transfusions. No significant histopathologic changes were found in any organ system. Rapid infusion of citrated blood causes myocardial depression, which can be reversed by giving calcium. Overall performance of the device was excellent, suggesting further documentation in a clinical setting and evaluation with human blood.
一种新型自体输血装置在犬类身上进行了评估。该装置使用枸橼酸盐磷酸盐葡萄糖作为血液抗凝剂，并以接近库存血中发现的比例自动输送该制剂。大约3个估计血容量的出血、抽吸和自体输血在血液学和凝血研究中产生了微小变化。血液电解质保持在正常范围内。输注2个血容量后活化凝血时间保持在正常范围内，但输注3个血容量后略有增加。在任何器官系统中均未发现明显的组织病理学变化。快速输注枸橼酸化血液会导致心肌抑制，给予钙剂可使其逆转。该装置的总体性能极佳，表明需要在临床环境中进一步记录并用人体血液进行评估。
