Dell Aquila Luiz Phellipe, Morales Armando, Moreira Patricia, Cendoroglo Maysa Seabra, Elias Rosilene Motta, Dalboni Maria Aparecida
Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
Universidade Federal de São Paulo (UNIFEP), São Paulo, Brazil.
J Clin Transl Endocrinol. 2023 Sep 15;34:100324. doi: 10.1016/j.jcte.2023.100324. eCollection 2023 Dec.
In postmenopausal women, vitamin D deficiency has been associated with disability, low muscle mass and fractures. Irisin is an important myokine that may contribute to the maintenance of muscle and bone density. Vitamin D is associated with the growth and function of muscle tissue through interactions between the vitamin D receptor and PGC-1α and activation of p38/MAPK (mitogen-activated protein kinase) in muscle, a mechanism similar to irisin action. The aim of this pilot study was to evaluate the effects of cholecalciferol supplementation on serum irisin levels in sedentary postmenopausal women with hypovitaminosis D (25(OH)D < 20 ng/mL).
80 sedentary postmenopausal women with hypovitaminosis D and low sun exposure were supplemented with cholecalciferol (30,000 IU/month) for 12 months. Calcium, parathyroid hormone, alkaline phosphatase (AP) and irisin levels were measured before and after supplementation.
25(OH) vitamin D increased in all participants. Serum levels of irisin increased (from 0.52 ± 0.27 to 0.80 ± 0.53; p < 0.003), accompanied by a decrease in AP (from 80 ± 24 to 66 ± 23; p < 0.001).
Restoration of vitamin D status increased serum irisin levels in sedentary postmenopausal women. Whether increased serum irisin levels may have an impact on clinical outcomes deserves further evaluation.
在绝经后女性中，维生素D缺乏与残疾、低肌肉量和骨折有关。鸢尾素是一种重要的肌动蛋白，可能有助于维持肌肉和骨密度。维生素D通过维生素D受体与PGC-1α之间的相互作用以及肌肉中p38/丝裂原活化蛋白激酶（MAPK）的激活，与肌肉组织的生长和功能相关，这一机制与鸢尾素的作用相似。本初步研究的目的是评估补充胆钙化醇对久坐不动且维生素D缺乏（25(OH)D < 20 ng/mL）的绝经后女性血清鸢尾素水平的影响。
80名久坐不动、维生素D缺乏且日照较少的绝经后女性补充胆钙化醇（30,000 IU/月），为期12个月。在补充前后测量钙、甲状旁腺激素、碱性磷酸酶（AP）和鸢尾素水平。
所有参与者的25(OH)维生素D均升高。血清鸢尾素水平升高（从0.52±0.27升至0.80±0.53；p < 0.003），同时AP降低（从80±24降至66±23；p < 0.001）。
恢复维生素D状态可提高久坐不动的绝经后女性的血清鸢尾素水平。血清鸢尾素水平升高是否会对临床结局产生影响值得进一步评估。
