Bravo Edgar, Maldonado Irma L, Razo Marco A, Martinez Gloria V, Lopez Sergio
Critical Care Medicine, General Hospital León, León, MEX.
Research Department, University of Guanajuato, León, MEX.
Cureus. 2023 Aug 21;15(8):e43873. doi: 10.7759/cureus.43873. eCollection 2023 Aug.
Background Severe disease from COVID-19 was the leading cause of admission to the emergency room and hospitalization during the pandemic in Mexico. Acute kidney injury was one of the most prevalent complications in these patients. The neutrophil/lymphocyte (NL) index and the neutrophil/lymphocyte platelet (NLP) index have previously been described as possible markers associated with complications and mortality in this disease. Objective To determine the association of the NL ratio and the NLP ratio in patients with acute kidney injury secondary to severe COVID-19. Materials and methods This is a case-control study, unpaired, of patients diagnosed with severe COVID-19 who presented or did not present acute kidney injury. On admission to the hospital, the hematological ratios were calculated, and Mann-Whitney U tests and multivariate logistic regression were performed. Results A total of 160 patients were included, and a difference in the NLP ratio (4.2 vs. 3.1, p = 0.001) was observed between patients with and without acute kidney injury. Additionally, the NLP ratio was the main risk variable for acute kidney injury in severe COVID-19, with an odds ratio of 2.5 and a 95% confidence interval of 1.108-5.66. Conclusions The NLP ratio has a moderate association and is a risk factor associated with the presence of acute kidney injury in patients with severe COVID-19.
在墨西哥大流行期间，新冠肺炎重症是急诊室收治和住院的主要原因。急性肾损伤是这些患者中最常见的并发症之一。中性粒细胞/淋巴细胞（NL）指数和中性粒细胞/淋巴细胞血小板（NLP）指数此前已被描述为与该疾病的并发症和死亡率相关的可能标志物。目的：确定重症新冠肺炎继发急性肾损伤患者的NL比值和NLP比值之间的关联。材料与方法：这是一项非配对病例对照研究，研究对象为诊断为重症新冠肺炎且出现或未出现急性肾损伤的患者。入院时计算血液学比值，并进行曼-惠特尼U检验和多因素逻辑回归分析。结果：共纳入了160例患者，观察到有急性肾损伤和无急性肾损伤患者之间的NLP比值存在差异（4.2对3.1，p = 0.001）。此外，NLP比值是重症新冠肺炎患者发生急性肾损伤的主要风险变量，比值比为2.5，95%置信区间为[1.108, 5.66]。结论：NLP比值存在中度关联，是重症新冠肺炎患者发生急性肾损伤的一个风险因素。
