Chang Ya-Chieh, Tsai Ping-Huang, Chou Yu-Ching, Lu Kuo-Cheng, Chang Feng-Yee, Wu Chia-Chao
Department of Internal Medicine, Division of Nephrology, Taoyuan Armed Forces General Hospital, Taoyuan 325, Taiwan.
Department of Internal Medicine, Division of Nephrology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
J Pers Med. 2021 May 19;11(5):432. doi: 10.3390/jpm11050432.
The catastrophic coronavirus disease 2019 (COVID-19) pandemic is currently a critical global issue. One well-known complication of COVID-19 in severe cases is acute kidney injury, but no research has given a description of its impact on the kidney in patients with mild symptoms. We explore the renal function changes in mild COVID-19 patients. This retrospective, single-center study included 27 participants with laboratory-detected severe acute respiratory syndrome coronavirus two (SARS-CoV-2) infection who were admitted to the Tri-Service General Hospital from 4 February to 26 May 2020 and analyzed their clinical features, radiological findings, and laboratory data. Data collected upon admission and discharge showed a median estimated glomerular filtration rate (eGFR) of 106.7 mL/min/1.732 m and 112.2 mL/min/1.732 m, respectively, with a -value of 0.044. A correlation between renal function and the severity of infection was also found and was statistically significant upon admission. Patients with a lower lymphocyte count or higher C-reactive protein, neutrophil count, and neutrophil-to-lymphocyte ratio presented with a decreased eGFR during their early infection phase. The biomarkers (CRP and NLR) may be linked with dynamic changes of renal function in COVID-19 patients who are asymptomatic or have mild symptoms.
2019年冠状病毒病（COVID-19）大流行目前是一个严峻的全球问题。COVID-19严重病例的一个众所周知的并发症是急性肾损伤，但尚无研究描述其对轻症患者肾脏的影响。我们探讨轻症COVID-19患者的肾功能变化。这项回顾性单中心研究纳入了2020年2月4日至5月26日入住三军总医院的27名经实验室检测确诊感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的参与者，并分析了他们的临床特征、影像学表现和实验室数据。入院和出院时收集的数据显示，估计肾小球滤过率（eGFR）中位数分别为106.7 mL/min/1.732 m²和112.2 mL/min/1.732 m²，P值为0.044。还发现肾功能与感染严重程度之间存在相关性，且入院时具有统计学意义。淋巴细胞计数较低或C反应蛋白、中性粒细胞计数及中性粒细胞与淋巴细胞比值较高的患者在感染早期eGFR降低。生物标志物（CRP和NLR）可能与无症状或轻症COVID-19患者肾功能的动态变化有关。
